Association between Intrapancreatic Fat Deposition and Lower High-Density Lipoprotein Cholesterol in Individuals with Newly Diagnosed T2DM.

IF 2.3 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

International Journal of Endocrinology Pub Date : 2023-01-01 DOI:10.1155/2023/6991633

Jianliang Wang, Qingyun Cai, Xiaojuan Wu, Jiaxuan Wang, Xiaona Chang, Xiaoyu Ding, Jia Liu, Guang Wang

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Abstract

Background: Intrapancreatic fat deposition (IPFD) usually occurs in individuals with type 2 diabetes mellitus (T2DM), but its physiopathological influence remains controversial. The present study aimed to investigate IPFD and its associations with various aspects of glucose and lipid metabolism in individuals with newly diagnosed T2DM.

Methods: A total of 100 individuals were included, consisting of 80 patients with newly diagnosed T2DM and 20 age- and sex-matched healthy controls. Then, we assessed IPFD using magnetic resonance imaging (MRI) and various parameters of glucose and lipid metabolism.

Results: Individuals with newly diagnosed T2DM had a significantly higher IPFD (median: 12.34%; IQR, 9.19-16.60%) compared with healthy controls (median: 6.35%; IQR, 5.12-8.96%) (p < 0.001). In individuals with newly diagnosed T2DM, IPFD was significantly associated with FINS and HOMA-IR in unadjusted model (β = 0.239, p=0.022; β = 0.578, p=0.007, respectively) and adjusted model for age and sex (β = 0.241, p=0.022; β = 0.535, p=0.014, respectively), but these associations vanished after adjustment for age, sex, and BMI. The OR of lower HDL-C for the prevalence of high IPFD was 4.22 (95% CI, 1.41 to 12.69; p=0.010) after adjustment for age, sex, BMI, and HbA1c.

Conclusions: Lower HDL-C was an independent predictor for a high degree of IPFD.

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新诊断T2DM患者胰腺内脂肪沉积与低高密度脂蛋白胆固醇之间的关系

背景:胰腺内脂肪沉积(IPFD)常见于2型糖尿病(T2DM)患者，但其生理病理影响仍有争议。本研究旨在探讨IPFD及其与新诊断T2DM个体糖脂代谢各方面的关系。方法:共纳入100例，包括80例新诊断的T2DM患者和20例年龄和性别匹配的健康对照。然后，我们使用磁共振成像(MRI)和糖脂代谢的各种参数评估IPFD。结果:新诊断T2DM的个体IPFD显著升高(中位数:12.34%;IQR, 9.19-16.60%)与健康对照(中位数:6.35%;IQR, 5.12-8.96%) (p < 0.001)。在未调整模型中，新诊断T2DM患者IPFD与FINS和HOMA-IR显著相关(β = 0.239, p=0.022;β = 0.578, p=0.007)和调整后的年龄和性别模型(β = 0.241, p=0.022;β = 0.535, p=0.014)，但在调整年龄、性别和BMI后，这些相关性消失。低HDL-C与高IPFD患病率的比值为4.22 (95% CI, 1.41 ~ 12.69;p=0.010)，校正了年龄、性别、BMI和HbA1c。结论:低HDL-C是IPFD高程度的独立预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Endocrinology ENDOCRINOLOGY & METABOLISM-

CiteScore

5.20

自引率

0.00%

发文量

147

审稿时长

1 months

期刊介绍： International Journal of Endocrinology is a peer-reviewed, Open Access journal that provides a forum for scientists and clinicians working in basic and translational research. The journal publishes original research articles, review articles, and clinical studies that provide insights into the endocrine system and its associated diseases at a genomic, molecular, biochemical and cellular level.