Anxiety Constitutes an Early Sign of Acute Hypoglycemia.

IF 2.3 4区心理学 Q3 NEUROSCIENCES

Neuropsychobiology Pub Date : 2023-01-01 DOI:10.1159/000528351

Ana G Gutiérrez García, Carlos M Contreras

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引用次数: 2

Abstract

Introduction: Research in humans has identified a link between hypoglycemia and anxiety. The present study examined anxiety-like behaviors in rats that were subjected to hypoglycemia that was produced by an acute injection of insulin. Healthy female Wistar rats were subjected to a battery of tests to explore anxiety (elevated plus maze) and locomotion (open field test).

Methods: The control (CT) group received 0.9% saline (3 mL/kg, p.o.). Three other groups received 50% glucose (3 mL/kg, p.o.), insulin (0.1 UI, s.c.), or insulin + glucose (normalized glycemia [NG] group).

Results: Normal glycemic values were found in the CT and NG groups. Therefore, a single control (CT-NG) group was formed for statistical comparisons. The highest glycemic value was found in the glucose-induced hyperglycemia group. The lowest glycemic value was found in the insulin-induced hypoglycemia group. In the open field test, the most significant change was a higher number of rearings in the hypoglycemia group. In the elevated plus maze test, the CT-NG group and hyperglycemia groups exhibited similar behavior, whereas the hypoglycemia group spent a shorter time on the open arms and a longer time on the closed arms and had the highest Anxiety Index. Hyperglycemia is a typical characteristic of diabetes. Insulin normalizes glycemia. In the present study, insulin produced anxiety only when it produced hypoglycemia.

Conclusion: The main effect of acute hypoglycemia is anxiety, which may be considered an early sign of hypoglycemia in an allostatic process.

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焦虑是急性低血糖症的早期征兆。

导读:对人类的研究已经确定了低血糖和焦虑之间的联系。目前的研究检查了急性注射胰岛素导致低血糖的大鼠的焦虑样行为。以健康雌性Wistar大鼠为研究对象，进行焦虑探索(升高+迷宫)和运动探索(野外测试)。方法:对照组(CT)给予0.9%生理盐水(3 mL/kg, p.o.)。其他三组给予50%葡萄糖(3ml /kg, p.o.)、胰岛素(0.1 UI, s.c)或胰岛素+葡萄糖(正常化血糖[NG]组)。结果:CT组和NG组血糖值正常。因此，我们组成一个单对照(CT-NG)组进行统计学比较。血糖值最高的是糖源性高血糖组。胰岛素诱导的低血糖组血糖值最低。在野外试验中，最显著的变化是低血糖组的饲养数量增加。在升高+迷宫测试中，CT-NG组和高血糖组表现出相似的行为，而低血糖组在张开手臂上花费的时间较短，在闭合手臂上花费的时间较长，焦虑指数最高。高血糖症是糖尿病的典型特征。胰岛素使血糖正常。在目前的研究中，胰岛素只有在产生低血糖时才会产生焦虑。结论:急性低血糖的主要影响是焦虑，这可能被认为是适应过程中低血糖的早期征兆。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychobiology 医学-精神病学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.