Andrographis paniculata and Andrographolide - A Snapshot on Recent Advances in Nano Drug Delivery Systems against Cancer.

IF 2.8 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Rohitas Deshmukh, Aman Kumar Jain, Rajesh Singh, Swarnali Das Paul, Ranjit K Harwansh
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Abstract

Cancer is one of the deadliest illnesses of the 21st century. Chemotherapy and radiation therapies both have considerable side effects. Antitumor antibiotics are one of them. Coughs, common colds, fevers, laryngitis, and infectious disorders have all been treated with Andrographis paniculata for centuries. Extracts of Andrographis effectively treat various ailments, as well as cancer. The most active molecule in Andrographis paniculata is andrographolide a, diterpene, and lactone. Andrographis paniculata and its derivatives have long been used to treat various ailments. Anti-inflammatory and cancerfighting characteristics have been observed in Andrographolide. Andrographolide, a diterpene lactone separated from Andrographis paniculata, has also been shown to have important criticalessential biological protective properties. It has also been suggested that it could be used to treat major human diseases like-rheumatoid like rheumatoid, colitis, and Parkinsons disease. This summary aims to highlight Andrographolide as a promising cancer treatment option. Several databases were searched for andrographolides cytotoxic/anti-cancer effects in pre-clinical and clinical research to serve this purpose. Several studies have shown that Andrographolide is helpful in cancer medication, as detailed in this review.

穿心莲和穿心莲内酯--抗癌纳米给药系统的最新进展掠影。
癌症是 21 世纪最致命的疾病之一。化疗和放疗都有相当大的副作用。抗肿瘤抗生素就是其中之一。几个世纪以来,人们一直用穿心莲治疗咳嗽、普通感冒、发烧、咽喉炎和传染性疾病。穿心莲提取物可有效治疗各种疾病和癌症。穿心莲中最活跃的分子是穿心莲内酯 a、二萜和内酯。穿心莲及其衍生物长期以来一直被用于治疗各种疾病。据观察,穿心莲内酯具有抗炎和抗癌特性。穿心莲内酯是从穿心莲中分离出来的一种二萜内酯,也被证明具有重要的重要生物保护特性。还有人认为,穿心莲内酯可用于治疗类风湿、结肠炎和帕金森病等人类重大疾病。本摘要旨在强调穿心莲内酯是一种有前途的癌症治疗选择。为此,我们在多个数据库中搜索了穿心莲内酯在临床前和临床研究中的细胞毒性/抗癌作用。多项研究表明穿心莲内酯有助于癌症治疗,本综述对此进行了详细介绍。
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来源期刊
Current drug delivery
Current drug delivery PHARMACOLOGY & PHARMACY-
CiteScore
5.10
自引率
4.20%
发文量
170
期刊介绍: Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.
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