Multifunctional 3D-printed bioceramic scaffolds: Recent strategies for osteosarcoma treatment.

IF 6.7 1区 工程技术 Q1 CELL & TISSUE ENGINEERING
Xingran Liu, Yihao Liu, Lei Qiang, Ya Ren, Yixuan Lin, Han Li, Qiuhan Chen, Shuxin Gao, Xue Yang, Changru Zhang, Minjie Fan, Pengfei Zheng, Shuai Li, Jinwu Wang
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引用次数: 0

Abstract

Osteosarcoma is the most prevalent bone malignant tumor in children and teenagers. The bone defect, recurrence, and metastasis after surgery severely affect the life quality of patients. Clinically, bone grafts are implanted. Primary bioceramic scaffolds show a monomodal osteogenesis function. With the advances in three-dimensional printing technology and materials science, while maintaining the osteogenesis ability, scaffolds become more patient-specific and obtain additional anti-tumor ability with functional agents being loaded. Anti-tumor therapies include photothermal, magnetothermal, old and novel chemo-, gas, and photodynamic therapy. These strategies kill tumors through novel mechanisms to treat refractory osteosarcoma due to drug resistance, and some have shown the potential to reverse drug resistance and inhibit metastasis. Therefore, multifunctional three-dimensional printed bioceramic scaffolds hold excellent promise for osteosarcoma treatments. To better understand, we review the background of osteosarcoma, primary 3D-printed bioceramic scaffolds, and different therapies and have a prospect for the future.

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多功能3d打印生物陶瓷支架:骨肉瘤治疗的最新策略。
骨肉瘤是儿童和青少年中最常见的骨恶性肿瘤。术后骨缺损、复发、转移严重影响患者的生活质量。临床上,骨移植物被植入。初级生物陶瓷支架具有单峰成骨功能。随着三维打印技术和材料科学的进步,支架在保持成骨能力的同时,更加具有患者特异性,并通过加载功能剂获得额外的抗肿瘤能力。抗肿瘤疗法包括光热疗法、磁热疗法、新旧化疗、气体疗法和光动力疗法。这些策略通过新的机制杀死肿瘤以治疗耐药难治性骨肉瘤,其中一些已显示出逆转耐药和抑制转移的潜力。因此,多功能三维打印生物陶瓷支架在骨肉瘤治疗中具有良好的前景。为了更好地了解骨肉瘤,我们回顾了骨肉瘤的背景,原发性3d打印生物陶瓷支架,以及不同的治疗方法,并对未来进行了展望。
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来源期刊
Journal of Tissue Engineering
Journal of Tissue Engineering Engineering-Biomedical Engineering
CiteScore
11.60
自引率
4.90%
发文量
52
审稿时长
12 weeks
期刊介绍: The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.
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