Longitudinal changes in metabolic network activity in early Alzheimer's disease

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2023-05-19 DOI:10.1002/alz.13137

Matej Perovnik, Chris C. Tang, Mauro Namías, David Eidelberg, Alzheimer's Disease Neuroimaging Initiative (ADNI)

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引用次数: 2

Abstract

INTRODUCTION

The progression of Alzheimer's disease (AD) has been linked to two metabolic networks, the AD-related pattern (ADRP) and the default mode network (DMN).

METHODS

Converting and clinically stable cognitively normal subjects (n = 47) and individuals with mild cognitive impairment (n = 96) underwent 2-[¹⁸F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) three or more times over 6 years (n_scans = 705). Expression levels for ADRP and DMN were measured in each subject and time point, and the resulting changes were correlated with cognitive performance. The role of network expression in predicting conversion to dementia was also evaluated.

RESULTS

Longitudinal increases in ADRP expression were observed in converters, while age-related DMN loss was seen in converters and nonconverters. Cognitive decline correlated with increases in ADRP and declines in DMN, but conversion to dementia was predicted only by baseline ADRP levels.

DISCUSSION

The results point to the potential utility of ADRP as an imaging biomarker of AD progression.

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早期阿尔茨海默病中代谢网络活动的纵向变化

阿尔茨海默病(AD)的进展与两个代谢网络有关，AD相关模式(ADRP)和默认模式网络(DMN)。方法转换和临床稳定的认知正常受试者(n = 47)和轻度认知障碍患者(n = 96)在6年内接受了3次或以上的2-[18F]氟-2-脱氧-d -葡萄糖(FDG)正电子发射断层扫描(PET) (nscan = 705)。在每个受试者和时间点测量ADRP和DMN的表达水平，结果变化与认知表现相关。网络表达在预测痴呆转化中的作用也被评估。结果:在皈依者中观察到ADRP表达的纵向增加，而在皈依者和非皈依者中观察到与年龄相关的DMN丢失。认知能力下降与ADRP的增加和DMN的下降相关，但仅通过基线ADRP水平预测转化为痴呆。研究结果指出ADRP作为AD进展的成像生物标志物的潜在效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.