Oxidative stress parameters and their relation to motor subtype of Parkinson's disease and levodopa treatment status.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Milan Grofik, Michal Cibulka, Jana Oleksakova, Stefan Sivak, Daniel Cierny, Zuzana Tatarkova, Marian Grendar, Vladimir Nosal, Robert Ruzinak, Egon Kurca, Martin Kolisek
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引用次数: 0

Abstract

Parkinson's disease (PD) is an oxidative stress-linked neurodegenerative disorder, with the highest prevalence among seniors. The objective of this study were: (1) to analyse levels of following oxidative stress parameters: total antioxidant capacity (TAC), uric acid (UA), total glutathione (tGSH), bilirubin (Bil) and albumin (Alb), in blood of PD patients and healthy controls; (2) to find possible associations of examined oxidative stress parameters with PD subtypes and levodopa treatment status; and (3) to evaluate power and relevance of the aforementioned oxidative stress parameter for the prediction of onset and progression of PD by utilizing Random Forest machine learning (RFML). Oxidative stress parameters were determined in 125 PD patients and 55 healthy controls. Evaluated with frequentist statistics, our data revealed that UA is the only oxidative stress parameter associated with PD. However, when the PD cohort was divided in gender-dependent manner, tGSH and Bil were also significantly associated with PD in subgroup of female patients. RFML rendered no predictive power of any of the tested oxidative stress parameters in respect to PD, its subtypes, and/or status of levodopa treatment. In conclusion, despite the positive association of UA with PD (in complete cohort of PD patients) and of tGSH and Bil with PD but only in female patients, these oxidative stress parameters are of no use in clinical practice due to the lack of the predictive/diagnostic power.

氧化应激参数及其与帕金森病运动亚型和左旋多巴治疗状况的关系
帕金森病(PD)是一种与氧化应激相关的神经退行性疾病,在老年人中发病率最高。本研究的目的是:(1)分析PD患者和健康对照组血液中以下氧化应激参数的水平:总抗氧化能力(TAC)、尿酸(UA)、总谷胱甘肽(tGSH)、胆红素(Bil)和白蛋白(Alb);(2)寻找氧化应激参数与PD亚型和左旋多巴治疗状态的可能关联;(3)利用随机森林机器学习(RFML)评估上述氧化应激参数对PD发病和进展的预测能力和相关性。测定125例PD患者和55名健康对照者的氧化应激参数。通过频率统计,我们的数据显示UA是与PD相关的唯一氧化应激参数。然而,当PD队列以性别依赖方式划分时,tGSH和Bil在女性患者亚组中也与PD显著相关。RFML对PD、其亚型和/或左旋多巴治疗状态的任何氧化应激参数均无预测能力。总之,尽管UA与PD呈正相关(在PD患者的完整队列中),tGSH和Bil与PD呈正相关(但仅在女性患者中),但由于缺乏预测/诊断能力,这些氧化应激参数在临床实践中没有使用。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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