Effects of BPA substitutes on the prenatal and cardiovascular systems.

IF 5.7 2区医学 Q1 TOXICOLOGY

Critical Reviews in Toxicology Pub Date : 2022-07-01 DOI:10.1080/10408444.2022.2142514

Fatima Abrantes-Soares, Margarida Lorigo, Elisa Cairrao

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引用次数: 8

Abstract

Bisphenol A (BPA) is a ubiquitous chemical compound constantly being released into the environment, making it one of the most persistent endocrine-disrupting chemical (EDC) in nature. This EDC has already been associated with developing various pathologies, such as diabetes, obesity, and cardiovascular, renal, and behavioral complications, among others. Therefore, over the years, BPA has been replaced, gradually, by its analog compounds. However, these compounds are structurally similar to BPA, so, in recent years, questions have been raised concerning their safety for human health. Numerous investigations have been performed to determine the effects BPA substitutes may cause, particularly during pregnancy and prenatal life. On the other hand, studies investigating the association of these compounds with the development of cardiovascular diseases (CVD) have been developed. In this sense, this review summarizes the existing literature on the transgenerational transfer of BPA substitutes and the consequent effects on maternal and offspring health following prenatal exposure. In addition, these compounds' effects on the cardiovascular system and the susceptibility to develop CVD will be presented. Therefore, this review aims to highlight the need to investigate further the safety and benefits, or hazards, associated with replacing BPA with its analogs.

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BPA替代品对产前和心血管系统的影响。

双酚A (BPA)是一种无处不在的化合物，不断释放到环境中，使其成为自然界中最持久的内分泌干扰化学物质(EDC)之一。这种EDC已经与各种病理的发展有关，如糖尿病、肥胖、心血管、肾脏和行为并发症等。因此，多年来，双酚a已逐渐被其类似化合物所取代。然而，这些化合物在结构上与双酚a相似，因此，近年来，人们对它们对人体健康的安全性提出了质疑。为了确定BPA替代品可能造成的影响，特别是在怀孕和产前生活期间，已经进行了大量的调查。另一方面，已经开展了调查这些化合物与心血管疾病(CVD)发展之间关系的研究。从这个意义上说，本文综述了现有的关于双酚a代用品的代际转移及其对产前暴露后母亲和后代健康的影响的文献。此外，还将介绍这些化合物对心血管系统的影响以及发生CVD的易感性。因此，这篇综述的目的是强调有必要进一步调查用类似物代替双酚a的安全性、益处或危害。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Toxicology 医学-毒理学

CiteScore

9.50

自引率

1.70%

发文量

期刊介绍： Critical Reviews in Toxicology provides up-to-date, objective analyses of topics related to the mechanisms of action, responses, and assessment of health risks due to toxicant exposure. The journal publishes critical, comprehensive reviews of research findings in toxicology and the application of toxicological information in assessing human health hazards and risks. Toxicants of concern include commodity and specialty chemicals such as formaldehyde, acrylonitrile, and pesticides; pharmaceutical agents of all types; consumer products such as macronutrients and food additives; environmental agents such as ambient ozone; and occupational exposures such as asbestos and benzene.