Salfarina Iberahim, Noor Haslina Mohd Noor, Mohd Nazri Hassan, Rosnah Bahar, Shafini Mohdmed Yusoff, Marini Ramli, Wan Suriana Wan Abdul Rahman, Zefarina Zulkafli, Marne Abdullah, Ho Sook Fong, Tengku Muzafar Tengku Mohamed Shihabudin, Hisham Atan Edinur, Norul Hajar Che Ghazali
{"title":"A case of naturally occurring anti-Di<sup>a</sup> antibody in a young man.","authors":"Salfarina Iberahim, Noor Haslina Mohd Noor, Mohd Nazri Hassan, Rosnah Bahar, Shafini Mohdmed Yusoff, Marini Ramli, Wan Suriana Wan Abdul Rahman, Zefarina Zulkafli, Marne Abdullah, Ho Sook Fong, Tengku Muzafar Tengku Mohamed Shihabudin, Hisham Atan Edinur, Norul Hajar Che Ghazali","doi":"10.4103/ajts.ajts_136_21","DOIUrl":null,"url":null,"abstract":"<p><p>The Diego (Di) blood group system comprises 22 antigens located on the band 3 protein, most of which are low-prevalence antigens. The majority of antibodies to Diego system antigens were of clinically insignificant; however anti-Dia, -Dib, -Wra, -ELO and-DISK may cause hemolytic disease of the fetus and newborn (HDFN) and transfusion reaction. We reported a case of naturally occurring of anti-Dia in a young man who presented to our hospital for wound debridement of fingers injury. His serological results were suggestive of anti-Dia antibody, and his molecular blood group showed he has Di (a-b+) antigen. Anti-Dia may be clinically significant. It can cause mild-to-severe HDFN, but there are only infrequent reports of it being clearly implicated in a hemolytic transfusion reaction. We suggest the need for reagent red blood cell panels to include Dia antigen-positive cells in antibody identification tests for our populations.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"16 2","pages":"276-279"},"PeriodicalIF":0.6000,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/8e/AJTS-16-276.PMC9855223.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Transfusion Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ajts.ajts_136_21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/11/12 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"HEMATOLOGY","Score":null,"Total":0}
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Abstract
The Diego (Di) blood group system comprises 22 antigens located on the band 3 protein, most of which are low-prevalence antigens. The majority of antibodies to Diego system antigens were of clinically insignificant; however anti-Dia, -Dib, -Wra, -ELO and-DISK may cause hemolytic disease of the fetus and newborn (HDFN) and transfusion reaction. We reported a case of naturally occurring of anti-Dia in a young man who presented to our hospital for wound debridement of fingers injury. His serological results were suggestive of anti-Dia antibody, and his molecular blood group showed he has Di (a-b+) antigen. Anti-Dia may be clinically significant. It can cause mild-to-severe HDFN, but there are only infrequent reports of it being clearly implicated in a hemolytic transfusion reaction. We suggest the need for reagent red blood cell panels to include Dia antigen-positive cells in antibody identification tests for our populations.
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