Cardiovascular Disease Risk Reduction and Body Mass Index.

IF 3.9 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Rohan Samson, Pierre Vladimir Ennezat, Thierry H Le Jemtel, Suzanne Oparil
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引用次数: 5

Abstract

Purpose of review: Anti-hypertensive and lipid lowering therapy addresses only half of the cardiovascular disease risk in patients with body mass index > 30 kg/m2, i.e., obesity. We examine newer aspects of obesity pathobiology that underlie the partial effectiveness of anti-hypertensive lipid lowering therapy for the reduction of cardiovascular disease risk in obesity.

Recent findings: Obesity-related insulin resistance, vascular endothelium dysfunction, increased sympathetic nervous system/renin-angiotensin-aldosterone system activity, and glomerulopathy lead to type 2 diabetes, coronary atherosclerosis, and chronic disease kidney disease that besides hypertension and dyslipidemia increase cardiovascular disease risk. Obesity increases cardiovascular disease risk through multiple pathways. Optimal reduction of cardiovascular disease risk in patients with obesity is likely to require therapy targeted at both obesity and obesity-associated conditions.

降低心血管疾病风险和身体质量指数。
综述目的:降压降脂治疗只能解决体重指数> 30 kg/m2的患者心血管疾病风险的一半,即肥胖。我们研究了肥胖病理生物学的新方面,这些方面是抗高血压降脂疗法降低肥胖患者心血管疾病风险的部分有效性的基础。最近的研究发现:肥胖相关的胰岛素抵抗、血管内皮功能障碍、交感神经系统/肾素-血管紧张素-醛固酮系统活性增加和肾小球病变导致2型糖尿病、冠状动脉粥样硬化和慢性肾病,这些疾病除了高血压和血脂异常外,还会增加心血管疾病的风险。肥胖通过多种途径增加心血管疾病的风险。肥胖患者心血管疾病风险的最佳降低可能需要针对肥胖和肥胖相关疾病的治疗。
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来源期刊
Current Hypertension Reports
Current Hypertension Reports 医学-外周血管病
CiteScore
10.50
自引率
0.00%
发文量
65
审稿时长
6-12 weeks
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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