Dietary advanced glycation end-products elicit toxicological effects by disrupting gut microbiome and immune homeostasis.

IF 2.4 4区医学 Q3 TOXICOLOGY

Journal of Immunotoxicology Pub Date : 2021-07-24 DOI:10.1080/1547691X.2021.1959677

Yingjia Chen, Tai L Guo

{"title":"Dietary advanced glycation end-products elicit toxicological effects by disrupting gut microbiome and immune homeostasis.","authors":"Yingjia Chen, Tai L Guo","doi":"10.1080/1547691X.2021.1959677","DOIUrl":null,"url":null,"abstract":"<p><p>The aging immune system is characterized by a low-grade chronic systemic inflammatory state (\"inflammaging\") marked by elevated serum levels of inflammatory molecules such as interleukin (IL)-6 and C-reactive protein (CRP). These inflammatory markers were also reported to be strong predictors for the development/severity of Type 2 diabetes, obesity, and COVID-19. The levels of these markers have been positively associated with those of advanced glycation end-products (AGEs) generated via non-enzymatic glycation and oxidation of proteins and lipids during normal aging and metabolism. Based on the above observations, it is clinically important to elucidate how dietary AGEs modulate inflammation and might thus increase the risk for aging-exacerbated diseases. The present narrative review discusses the potential pro-inflammatory properties of dietary AGEs with a focus on the inflammatory mediators CRP, IL-6 and ferritin, and their relations to aging in general and Type 2 diabetes in particular. In addition, underlying mechanisms - including those related to gut microbiota and the receptors for AGEs, and the roles AGEs might play in affecting physiologies of the healthy elderly, obese individuals, and diabetics are discussed in regard to any greater susceptibility to COVID-19.</p>","PeriodicalId":16073,"journal":{"name":"Journal of Immunotoxicology","volume":"18 1","pages":"93-104"},"PeriodicalIF":2.4000,"publicationDate":"2021-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885815/pdf/nihms-1865814.pdf","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Immunotoxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/1547691X.2021.1959677","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"TOXICOLOGY","Score":null,"Total":0}

引用次数: 12

Abstract

The aging immune system is characterized by a low-grade chronic systemic inflammatory state ("inflammaging") marked by elevated serum levels of inflammatory molecules such as interleukin (IL)-6 and C-reactive protein (CRP). These inflammatory markers were also reported to be strong predictors for the development/severity of Type 2 diabetes, obesity, and COVID-19. The levels of these markers have been positively associated with those of advanced glycation end-products (AGEs) generated via non-enzymatic glycation and oxidation of proteins and lipids during normal aging and metabolism. Based on the above observations, it is clinically important to elucidate how dietary AGEs modulate inflammation and might thus increase the risk for aging-exacerbated diseases. The present narrative review discusses the potential pro-inflammatory properties of dietary AGEs with a focus on the inflammatory mediators CRP, IL-6 and ferritin, and their relations to aging in general and Type 2 diabetes in particular. In addition, underlying mechanisms - including those related to gut microbiota and the receptors for AGEs, and the roles AGEs might play in affecting physiologies of the healthy elderly, obese individuals, and diabetics are discussed in regard to any greater susceptibility to COVID-19.

Abstract Image

查看原文本刊更多论文

饮食晚期糖基化终产物通过破坏肠道微生物群和免疫稳态引起毒理学效应。

衰老的免疫系统以低级别慢性全身性炎症状态(“炎症”)为特征，其特征是血清中炎症分子(如白细胞介素(IL)-6和c反应蛋白(CRP))水平升高。据报道，这些炎症标志物也是2型糖尿病、肥胖和COVID-19发展/严重程度的有力预测因素。这些标志物的水平与正常衰老和代谢过程中通过非酶糖基化和蛋白质和脂质氧化产生的晚期糖基化终产物(AGEs)的水平呈正相关。基于上述观察结果，阐明膳食AGEs如何调节炎症，从而可能增加衰老加重疾病的风险，在临床上具有重要意义。本文讨论了膳食AGEs的潜在促炎特性，重点讨论了炎症介质CRP、IL-6和铁蛋白，以及它们与一般衰老和2型糖尿病的关系。此外，本文还讨论了潜在的机制，包括与肠道微生物群和AGEs受体相关的机制，以及AGEs在影响健康老年人、肥胖者和糖尿病患者的生理方面可能发挥的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Immunotoxicology 医学-毒理学

CiteScore

6.70

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Immunotoxicology is an open access, peer-reviewed journal that provides a needed singular forum for the international community of immunotoxicologists, immunologists, and toxicologists working in academia, government, consulting, and industry to both publish their original research and be made aware of the research findings of their colleagues in a timely manner. Research from many subdisciplines are presented in the journal, including the areas of molecular, developmental, pulmonary, regulatory, nutritional, mechanistic, wildlife, and environmental immunotoxicology, immunology, and toxicology. Original research articles as well as timely comprehensive reviews are published.