Bioenergetic Metabolism In Osteoblast Differentiation.

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Leyao Shen, Guoli Hu, Courtney M Karner
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引用次数: 17

Abstract

Purpose of review: Osteoblasts are responsible for bone matrix production during bone development and homeostasis. Much is known about the transcriptional regulation and signaling pathways governing osteoblast differentiation. However, less is known about how osteoblasts obtain or utilize nutrients to fulfill the energetic demands associated with osteoblast differentiation and bone matrix synthesis. The goal of this review is to highlight and discuss what is known about the role and regulation of bioenergetic metabolism in osteoblasts with a focus on more recent studies.

Recent findings: Bioenergetic metabolism has emerged as an important regulatory node in osteoblasts. Recent studies have begun to identify the major nutrients and bioenergetic pathways favored by osteoblasts as well as their regulation during differentiation. Here, we highlight how osteoblasts obtain and metabolize glucose, amino acids, and fatty acids to provide energy and other metabolic intermediates. In addition, we highlight the signals that regulate nutrient uptake and metabolism and focus on how energetic metabolism promotes osteoblast differentiation. Bioenergetic metabolism provides energy and other metabolites that are critical for osteoblast differentiation and activity. This knowledge contributes to a more comprehensive understanding of osteoblast biology and may inform novel strategies to modulate osteoblast differentiation and bone anabolism in patients with bone disorders.

Abstract Image

成骨细胞分化中的生物能量代谢。
综述目的:成骨细胞在骨发育和体内平衡过程中负责骨基质的生成。关于成骨细胞分化的转录调控和信号通路,我们知道的很多。然而,对于成骨细胞如何获取或利用营养物质来满足与成骨细胞分化和骨基质合成相关的能量需求,我们所知甚少。这篇综述的目的是强调和讨论关于生物能量代谢在成骨细胞中的作用和调节的已知内容,并重点讨论最近的研究。最近研究发现:生物能量代谢已成为成骨细胞的重要调控节点。近年来的研究已经开始确定成骨细胞所支持的主要营养物质和生物能量途径,以及它们在分化过程中的调节。在这里,我们强调成骨细胞如何获取和代谢葡萄糖、氨基酸和脂肪酸,以提供能量和其他代谢中间体。此外,我们强调了调节营养摄取和代谢的信号,并重点关注能量代谢如何促进成骨细胞分化。生物能量代谢提供对成骨细胞分化和活动至关重要的能量和其他代谢物。这些知识有助于更全面地了解成骨细胞生物学,并可能为骨疾病患者调节成骨细胞分化和骨合成代谢提供新的策略。
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来源期刊
Current Osteoporosis Reports
Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
8.80
自引率
2.30%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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