Beyond membrane components: uncovering the intriguing world of fungal sphingolipid synthesis and regulation

IF 2.5 4区生物学 Q3 MICROBIOLOGY

Research in microbiology Pub Date : 2023-09-01 DOI:10.1016/j.resmic.2023.104087

Sana Akhtar Usmani , Mohit Kumar , Khushboo Arya , Basharat Ali , Nitin Bhardwaj , Naseem Akhtar Gaur , Rajendra Prasad , Ashutosh Singh

引用次数: 2

Abstract

Sphingolipids (SLs) are essential to fungal survival and represent a major class of structural and signaling lipids. Unique SL structures and their biosynthetic enzymes in filamentous fungi make them an ideal drug target. Several studies have contributed towards the functional characterization of specific SL metabolism genes, which have been complemented by advanced lipidomics methods which allow accurate identification and quantification of lipid structures and pathway mapping. These studies have provided a better understanding of SL biosynthesis, degradation and regulation networks in filamentous fungi, which are discussed and elaborated here.

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超越膜成分：揭开真菌鞘脂合成和调节的迷人世界。

鞘氨醇脂质（SL）是真菌生存所必需的，是一类主要的结构和信号脂质。丝状真菌独特的SL结构及其生物合成酶使其成为理想的药物靶点。一些研究对特定SL代谢基因的功能表征做出了贡献，这些研究得到了先进的脂质组学方法的补充，这些方法可以准确识别和量化脂质结构和通路图。这些研究提供了对丝状真菌SL生物合成、降解和调节网络的更好理解，本文对此进行了讨论和阐述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in microbiology 生物-微生物学

CiteScore

4.10

自引率

3.80%

发文量

审稿时长

16 days

期刊介绍： Research in Microbiology is the direct descendant of the original Pasteur periodical entitled Annales de l''Institut Pasteur, created in 1887 by Emile Duclaux under the patronage of Louis Pasteur. The Editorial Committee included Chamberland, Grancher, Nocard, Roux and Straus, and the first issue began with Louis Pasteur''s "Lettre sur la Rage" which clearly defines the spirit of the journal:"You have informed me, my dear Duclaux, that you intend to start a monthly collection of articles entitled "Annales de l''Institut Pasteur". You will be rendering a service that will be appreciated by the ever increasing number of young scientists who are attracted to microbiological studies. In your Annales, our laboratory research will of course occupy a central position, but the work from outside groups that you intend to publish will be a source of competitive stimulation for all of us."That first volume included 53 articles as well as critical reviews and book reviews. From that time on, the Annales appeared regularly every month, without interruption, even during the two world wars. Although the journal has undergone many changes over the past 100 years (in the title, the format, the language) reflecting the evolution in scientific publishing, it has consistently maintained the Pasteur tradition by publishing original reports on all aspects of microbiology.