Group 2 Innate Lymphoid Cells: Team Players in Regulating Asthma.

IF 26.9 1区 医学 Q1 IMMUNOLOGY
Noe Rodriguez-Rodriguez, Mayuri Gogoi, Andrew N J McKenzie
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引用次数: 28

Abstract

Type 2 immunity helps protect the host from infection, but it also plays key roles in tissue homeostasis, metabolism, and repair. Unfortunately, inappropriate type 2 immune reactions may lead to allergy and asthma. Group 2 innate lymphoid cells (ILC2s) in the lungs respond rapidly to local environmental cues, such as the release of epithelium-derived type 2 initiator cytokines/alarmins, producing type 2 effector cytokines such as IL-4, IL-5, and IL-13 in response to tissue damage and infection. ILC2s are associated with the severity of allergic asthma, and experimental models of lung inflammation have shown how they act as playmakers, receiving signals variously from stromal and immune cells as well as the nervous system and then distributing cytokine cues to elicit type 2 immune effector functions and potentiate CD4+ T helper cell activation, both of which characterize the pathology of allergic asthma. Recent breakthroughs identifying stromal- and neuronal-derived microenvironmental cues that regulate ILC2s, along with studies recognizing the potential plasticity of ILC2s, have improved our understanding of the immunoregulation of asthma and opened new avenues for drug discovery.

先天淋巴样细胞:调节哮喘的团队成员。
2型免疫有助于保护宿主免受感染,但它在组织稳态、代谢和修复中也起着关键作用。不幸的是,不适当的2型免疫反应可能导致过敏和哮喘。肺中的2组先天淋巴样细胞(ILC2s)对局部环境信号反应迅速,如上皮源性2型启动细胞因子/警报因子的释放,在组织损伤和感染反应中产生2型效应细胞因子如IL-4、IL-5和IL-13。ILC2s与过敏性哮喘的严重程度有关,肺部炎症的实验模型已经表明它们如何发挥作用,接收来自基质和免疫细胞以及神经系统的各种信号,然后分配细胞因子线索,引发2型免疫效应功能和增强CD4+ T辅助细胞激活,这两者都是过敏性哮喘病理的特征。最近的突破鉴定了调节ILC2s的基质和神经元来源的微环境线索,以及认识到ILC2s潜在可塑性的研究,提高了我们对哮喘免疫调节的理解,并为药物发现开辟了新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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