Outer Membrane Vesicles: Biogenesis, Functions, and Issues.

IF 8 1区生物学 Q1 MICROBIOLOGY

Microbiology and Molecular Biology Reviews Pub Date : 2022-12-21 Epub Date: 2022-09-26 DOI:10.1128/mmbr.00032-22

Rokas Juodeikis, Simon R Carding

引用次数: 13

Abstract

This review focuses on nonlytic outer membrane vesicles (OMVs), a subtype of bacterial extracellular vesicles (BEVs) produced by Gram-negative organisms focusing on the mechanisms of their biogenesis, cargo, and function. Throughout, we highlight issues concerning the characterization of OMVs and distinguishing them from other types of BEVs. We also highlight the shortcomings of commonly used methodologies for the study of BEVs that impact the interpretation of their functionality and suggest solutions to standardize protocols for OMV studies.

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外膜囊泡：生物学发生、功能和问题。

这篇综述的重点是非溶解性外膜囊泡（OMVs），这是一种由革兰氏阴性菌产生的细菌细胞外囊泡（BEVs）的亚型，重点关注其生物发生、携带和功能的机制。在整个过程中，我们强调了与OMV的特性相关的问题，并将其与其他类型的纯电动汽车区分开来。我们还强调了影响其功能解释的纯电动汽车研究常用方法的缺点，并提出了标准化OMV研究协议的解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbiology and Molecular Biology Reviews 生物-微生物学

CiteScore

18.80

自引率

0.80%

发文量

期刊介绍： Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.