Associations of GHR, IGF-1 and IGFBP-3 expression in adipose tissue cells with obesity-related alterations in corresponding circulating levels and adipose tissue function in children.

IF 3.5 4区 生物学 Q2 ENDOCRINOLOGY & METABOLISM
Elena Kempf, Kathrin Landgraf, Tim Vogel, Ulrike Spielau, Robert Stein, Matthias Raschpichler, Jürgen Kratzsch, Wieland Kiess, Juraj Stanik, Antje Körner
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引用次数: 0

Abstract

Components of the growth hormone (GH) axis, such as insulin-like growth factor-1 (IGF-1), IGF-1 binding protein-3 (IGFBP-3), GH receptor (GHR) and GH-binding protein (GHBP), regulate growth and metabolic pathways. Here, we asked if serum levels of these factors are altered with overweight/obesity and if this is related to adipose tissue (AT) expression and/or increased fat mass. Furthermore, we hypothesized that expression of GHR, IGF-1 and IGFBP-3 is associated with AT function. Serum GHBP levels were increased in children with overweight/obesity throughout childhood, while for IGF-1 levels and the IGF-1/IGFBP-3 molar ratio obesity-related elevations were detectable until early puberty. Circulating levels did not correlate with AT expression of these factors, which was decreased with overweight/obesity. Independent from obesity, expression of GHR, IGF-1 and IGFBP-3 was related to AT dysfunction,and increased insulin levels. Serum GHBP was associated with liver fat percentage and transaminase levels. We conclude that obesity-related elevations in serum GHBP and IGF-1 are unlikely to be caused by increased AT mass and elevations in GHBP are more closely related to liver status in children. The diminished AT expression of these factors with childhood obesity may contribute to early AT dysfunction and a deterioration of the metabolic state.

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儿童脂肪组织细胞中GHR、IGF-1和IGFBP-3表达与肥胖相关循环水平和脂肪组织功能改变的关系
生长激素(GH)轴的组成部分,如胰岛素样生长因子-1 (IGF-1)、IGF-1结合蛋白-3 (IGFBP-3)、GH受体(GHR)和GH结合蛋白(GHBP),调节生长和代谢途径。在这里,我们询问这些因子的血清水平是否随着超重/肥胖而改变,以及这是否与脂肪组织(AT)表达和/或脂肪量增加有关。此外,我们假设GHR、IGF-1和IGFBP-3的表达与AT功能有关。超重/肥胖儿童的血清GHBP水平在整个儿童期都升高,而IGF-1水平和IGF-1/IGFBP-3摩尔比的升高直到青春期早期才被检测到。循环水平与这些因子的AT表达无关,随着超重/肥胖而降低。与肥胖无关,GHR、IGF-1和IGFBP-3的表达与AT功能障碍和胰岛素水平升高有关。血清GHBP与肝脏脂肪百分比和转氨酶水平相关。我们得出结论,肥胖相关的血清GHBP和IGF-1升高不太可能是由AT质量增加引起的,GHBP升高与儿童肝脏状况更密切相关。这些因子在儿童肥胖中AT表达的减少可能导致早期AT功能障碍和代谢状态的恶化。
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来源期刊
Adipocyte
Adipocyte Medicine-Histology
CiteScore
6.50
自引率
3.00%
发文量
46
审稿时长
32 weeks
期刊介绍: Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.
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