{"title":"Bacterial AB toxins and host-microbe interactions.","authors":"Jeongmin Song","doi":"10.1016/bs.ampbs.2022.06.002","DOIUrl":null,"url":null,"abstract":"<p><p>AB toxins are protein virulence factors secreted by many bacterial pathogens, contributing to the pathogenicity of the cognate bacteria. AB toxins consist of two functionally distinct components: the enzymatic \"A\" component for pathogenicity and the receptor-binding \"B\" component for toxin delivery. Consistently, unlike other virulence factors such as effectors, AB toxins do not require additional systems to deliver them to the target host cells. Target host cells are located in the infection site and/or located distantly from infected host cells. The first part of this review discusses the structural and functional features of single-peptide and multiprotein AB toxins in the context of host-microbe interactions, using several well-characterized examples. The second part of this review discusses toxin neutralization strategies, as well as applications of AB toxins relevant to developing intervention strategies against diseases.</p>","PeriodicalId":50953,"journal":{"name":"Advances in Microbial Physiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Microbial Physiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/bs.ampbs.2022.06.002","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/7/18 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
AB toxins are protein virulence factors secreted by many bacterial pathogens, contributing to the pathogenicity of the cognate bacteria. AB toxins consist of two functionally distinct components: the enzymatic "A" component for pathogenicity and the receptor-binding "B" component for toxin delivery. Consistently, unlike other virulence factors such as effectors, AB toxins do not require additional systems to deliver them to the target host cells. Target host cells are located in the infection site and/or located distantly from infected host cells. The first part of this review discusses the structural and functional features of single-peptide and multiprotein AB toxins in the context of host-microbe interactions, using several well-characterized examples. The second part of this review discusses toxin neutralization strategies, as well as applications of AB toxins relevant to developing intervention strategies against diseases.
AB 毒素是许多细菌病原体分泌的蛋白毒力因子，有助于提高同种细菌的致病性。AB 型毒素由两种功能截然不同的成分组成：酶 "A "成分用于致病，受体结合 "B "成分用于毒素传递。与效应物等其他毒力因子不同的是，AB 型毒素不需要额外的系统将其传递给目标宿主细胞。目标宿主细胞位于感染部位和/或远离受感染的宿主细胞。本综述的第一部分通过几个特征明显的例子，讨论了单肽和多蛋白 AB毒素在宿主-微生物相互作用中的结构和功能特征。综述的第二部分讨论了毒素中和策略，以及 AB毒素在制定疾病干预策略方面的应用。
期刊介绍：
Advances in Microbial Physiology publishes topical and important reviews, interpreting physiology to include all material that contributes to our understanding of how microorganisms and their component parts work. First published in 1967, the editors have always striven to interpret microbial physiology in the broadest context and have never restricted the contents to traditional views of whole cell physiology.
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