Postoperative use of steroids for peri-electrode edema after deep brain stimulation surgery: A retrospective cohort study

IF 4.8 1区医学 Q1 NEUROSCIENCES

CNS Neuroscience & Therapeutics Pub Date : 2023-09-16 DOI:10.1111/cns.14470

Bin Wu, Yuting Ling, Changming Zhang, Jiakun Xu, Chao Yang, Nan Jiang, Ling Chen, Jinlong Liu

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Abstract

Background

To review the incidence and extent of peri-electrode edema after DBS and to clarify the effect of postoperative use of steroids on the peri-electrode edema.

Methods

This retrospective cohort study included 250 patients who underwent bilateral subthalamic nucleus (STN) DBS surgery with intact MRI within 1 month after DBS surgery. Patients were divided into steroid and non-steroid groups, based on postoperative steroids use. The occurrence and extent of peri-electrode edema were compared between the two groups, and other associated factors were analyzed using univariate and multivariate methods.

Results

Peri-electrode edema >1 cm³ in at least one hemisphere was reported in 215 (86.00%) patients. The mean volume of peri-electrode edema observed in the steroid group was significantly smaller than in the non-steroid group (8.09 ± 8.47 cm³ vs 17.10 ± 16.90 cm³, p < 0.001). In the steroid group, 104 (32.91%) of the 316 implanted electrodes present with edema less than 1 cm³, whereas in the non-steroid group, only 27 (14.67%) of the 184 implanted electrodes present with edema less than 1 cm³ (p < 0.001). Multivariate analysis indicated that lesser peri-electrode edema was significantly associated with postoperative steroids use and general anesthesia.

Conclusions

Peri-electrode edema is common after DBS surgery, and postoperative steroids use reduces the occurrence and extent of peri-electrode edema.

Abstract Image

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脑深部刺激手术后使用类固醇治疗电极周围水肿：一项回顾性队列研究。

背景：回顾 DBS 术后电极周围水肿的发生率和程度，明确术后使用类固醇对电极周围水肿的影响：回顾性分析 DBS 术后电极周围水肿的发生率和程度，明确术后使用类固醇对电极周围水肿的影响：这项回顾性队列研究纳入了 250 名接受双侧丘脑下核（STN）DBS 手术并在 DBS 术后 1 个月内接受完整 MRI 检查的患者。根据术后使用类固醇的情况，将患者分为类固醇组和非类固醇组。比较两组患者电极周围水肿的发生率和程度，并采用单变量和多变量方法分析其他相关因素：215例（86.00%）患者的电极周围水肿至少有一个半球大于1立方厘米。类固醇组观察到的电极周围水肿平均体积明显小于非类固醇组（8.09 ± 8.47 cm3 vs 17.10 ± 16.90 cm3，p 3），而在非类固醇组，184 个植入电极中只有 27 个（14.67%）电极周围水肿小于 1 cm3（p 结论：类固醇组电极周围水肿平均体积明显小于非类固醇组（8.09 ± 8.47 cm3 vs 17.10 ± 16.90 cm3，p 3）：DBS 手术后电极周围水肿很常见，术后使用类固醇可减少电极周围水肿的发生并减轻其程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.