'Immunization during ART and ATI for HIV-1 vaccine discovery/development'.

IF 4.5 3区 医学 Q2 IMMUNOLOGY
Current Opinion in HIV and AIDS Pub Date : 2023-11-01 Epub Date: 2023-09-08 DOI:10.1097/COH.0000000000000817
Leonidas Stamatatos
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引用次数: 1

Abstract

Purpose of review: Explore whether immunization with germline-targeting Env immunogens during ART, followed by ATI, leads to the identification of viral envelope glycoproteins (Envs) that promote and guide the full maturation of broadly neutralizing antibody responses.

Recent findings: The HIV-1 envelope glycoprotein (Env) does not efficiently engage the germline precursors of broadly neutralizing antibodies (bnAbs). However, Env-derived proteins specifically designed to precisely do that, have been recently developed. These 'germline-targeting' Env immunogens activate naïve B cells that express the germline precursors of bnAbs but by themselves cannot guide their maturation towards their broadly neutralizing forms. This requires sequential immunizations with heterologous sets of Envs. These 'booster' Envs are currently unknown.

Summary: Combining germline-targeting Env immunization approaches during ART with ATI could lead to the identification of natural Envs that are responsible for the maturation of broadly neutralizing antibody responses during infection. Such Envs could then serve as booster immunogens to guide the maturation of glBCRs that have become activated by germline-targeting immunogens in uninfected subjects.

Abstract Image

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“用于HIV-1疫苗发现/开发的ART和ATI期间的免疫”。
综述目的:探讨在ART期间用种系靶向Env免疫原进行免疫接种,然后进行ATI,是否能鉴定出促进和引导广泛中和抗体反应完全成熟的病毒包膜糖蛋白(Envs)。最近的发现:HIV-1包膜糖蛋白(Env)不能有效地与广泛中和抗体(bnAbs)的种系前体结合。然而,最近已经开发出了专门为实现这一目的而设计的Env衍生蛋白质。这些“种系靶向”Env免疫原激活了表达bnAbs种系前体的幼稚B细胞,但其自身无法引导其成熟为广泛的中和形式。这需要用异源Env进行连续免疫。这些“助推器”环境目前未知。总结:在ART期间将种系靶向Env免疫方法与ATI相结合,可以鉴定出在感染期间负责广泛中和抗体反应成熟的天然Env。这样的Env可以作为加强免疫原来指导glBCR的成熟,这些glBCR已被未感染受试者的种系靶向免疫原激活。
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来源期刊
Current Opinion in HIV and AIDS
Current Opinion in HIV and AIDS IMMUNOLOGY-INFECTIOUS DISEASES
CiteScore
7.40
自引率
7.30%
发文量
115
审稿时长
6-12 weeks
期刊介绍: Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in HIV and AIDS features hand-picked review articles from our team of expert editors. With six disciplines published across the year – including HIV and ageing, a HIV vaccine, and epidemiology – every issue also contains annotated reference detailing the merits of the most important papers.
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