Osteoarticular Mycoses.

IF 19 1区 医学 Q1 MICROBIOLOGY
Clinical Microbiology Reviews Pub Date : 2022-12-21 Epub Date: 2022-11-30 DOI:10.1128/cmr.00086-19
Maria N Gamaletsou, Blandine Rammaert, Barry Brause, Marimelle A Bueno, Sanjeet S Dadwal, Michael W Henry, Aspasia Katragkou, Dimitrios P Kontoyiannis, Matthew W McCarthy, Andy O Miller, Brad Moriyama, Zoi Dorothea Pana, Ruta Petraitiene, Vidmantas Petraitis, Emmanuel Roilides, Jean-Pierre Sarkis, Maria Simitsopoulou, Nikolaos V Sipsas, Saad J Taj-Aldeen, Valérie Zeller, Olivier Lortholary, Thomas J Walsh
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引用次数: 10

Abstract

Osteoarticular mycoses are chronic debilitating infections that require extended courses of antifungal therapy and may warrant expert surgical intervention. As there has been no comprehensive review of these diseases, the International Consortium for Osteoarticular Mycoses prepared a definitive treatise for this important class of infections. Among the etiologies of osteoarticular mycoses are Candida spp., Aspergillus spp., Mucorales, dematiaceous fungi, non-Aspergillus hyaline molds, and endemic mycoses, including those caused by Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides species. This review analyzes the history, epidemiology, pathogenesis, clinical manifestations, diagnostic approaches, inflammatory biomarkers, diagnostic imaging modalities, treatments, and outcomes of osteomyelitis and septic arthritis caused by these organisms. Candida osteomyelitis and Candida arthritis are associated with greater events of hematogenous dissemination than those of most other osteoarticular mycoses. Traumatic inoculation is more commonly associated with osteoarticular mycoses caused by Aspergillus and non-Aspergillus molds. Synovial fluid cultures are highly sensitive in the detection of Candida and Aspergillus arthritis. Relapsed infection, particularly in Candida arthritis, may develop in relation to an inadequate duration of therapy. Overall mortality reflects survival from disseminated infection and underlying host factors.

Osteoarticular真菌病。
骨关节真菌病是慢性衰弱感染,需要延长疗程的抗真菌治疗,可能需要专家手术干预。由于没有对这些疾病的全面审查,国际骨关节真菌病联合会为这类重要的感染准备了一份权威的论文。骨关节真菌病的病因包括念珠菌、曲霉、毛霉菌、真菌、非曲霉透明霉菌和地方性真菌病,包括由荚膜组织原体、皮炎芽孢菌和球虫引起的真菌病。本文综述了由这些微生物引起的骨髓炎和脓毒性关节炎的历史、流行病学、发病机制、临床表现、诊断方法、炎症生物标志物、诊断成像方式、治疗和结局。念珠菌性骨髓炎和念珠菌性关节炎比大多数其他骨关节真菌病与更大的血液传播事件相关。创伤性接种更常与曲霉和非曲霉霉菌引起的骨关节真菌病有关。滑液培养是高度敏感的检测念珠菌和曲霉菌关节炎。复发性感染,特别是念珠菌关节炎,可能与治疗时间不足有关。总体死亡率反映了播散性感染和潜在宿主因素的生存率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical Microbiology Reviews
Clinical Microbiology Reviews 医学-微生物学
CiteScore
54.20
自引率
0.50%
发文量
38
期刊介绍: Clinical Microbiology Reviews (CMR) is a journal that primarily focuses on clinical microbiology and immunology.It aims to provide readers with up-to-date information on the latest developments in these fields.CMR also presents the current state of knowledge in clinical microbiology and immunology.Additionally, the journal offers balanced and thought-provoking perspectives on controversial issues in these areas.
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