Long Runs of Homozygosity Are Correlated with Marriage Preferences across Global Population Samples.

4区生物学 Q2 Medicine

Human Biology Pub Date : 2021-01-01 DOI:10.1353/hub.2021.0011

Samali Anova Sahoo, Rslan A Zaidi, Santosh Anagol, Iain Mathieson

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引用次数: 3

Abstract

Children of consanguineous unions carry long runs of homozygosity (ROH) in their genomes, due to their parents' recent shared ancestry. This increases the burden of recessive disease in populations with high levels of consanguinity and has been heavily studied in some groups. However, there has been little investigation of the broader effect of consanguinity on patterns of genetic variation on a global scale. This study, which collected published genetic data and information about marriage practice from 395 worldwide populations, shows that reported preference for cousin marriage has a detectable association with the distribution of long ROH in this sample, increasing the expected number of ROH longer than 10 cM by a factor of 2.2. Variation in marriage practice and consequent rates of consanguinity are therefore an important aspect of demographic history for the purposes of modeling human genetic variation. However, reported marriage practices explain a relatively small proportion of the variation in ROH distribution, and consequently, population genetic data are only partially informative about cultural preferences.

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在全球人口样本中，长期的同源性与婚姻偏好相关。

由于父母最近有共同的祖先，近亲结合的孩子在他们的基因组中携带长期的纯合性（ROH）。这增加了高血亲人群中隐性疾病的负担，一些群体对此进行了大量研究。然而，很少有人在全球范围内研究血缘关系对遗传变异模式的更广泛影响。这项研究收集了来自全球395个人群的已发表的基因数据和婚姻实践信息，结果表明，据报道，表亲婚姻的偏好与该样本中长ROH的分布有明显的关联，使超过10 cM的预期ROH数量增加了2.2倍。因此，为了模拟人类基因变异，婚姻实践的变异和由此产生的血亲率是人口统计学历史的一个重要方面。然而，报告的婚姻实践解释了ROH分布变化的相对较小比例，因此，人口遗传数据仅部分提供了有关文化偏好的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Biology 生物-生物学

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Human Biology publishes original scientific articles, brief communications, letters to the editor, and review articles on the general topic of biological anthropology. Our main focus is understanding human biological variation and human evolution through a broad range of approaches. We encourage investigators to submit any study on human biological diversity presented from an evolutionary or adaptive perspective. Priority will be given to interdisciplinary studies that seek to better explain the interaction between cultural processes and biological processes in our evolution. Methodological papers are also encouraged. Any computational approach intended to summarize cultural variation is encouraged. Studies that are essentially descriptive or concern only a limited geographic area are acceptable only when they have a wider relevance to understanding human biological variation. Manuscripts may cover any of the following disciplines, once the anthropological focus is apparent: human population genetics, evolutionary and genetic demography, quantitative genetics, evolutionary biology, ancient DNA studies, biological diversity interpreted in terms of adaptation (biometry, physical anthropology), and interdisciplinary research linking biological and cultural diversity (inferred from linguistic variability, ethnological diversity, archaeological evidence, etc.).