Nectin-4 is frequently expressed in primary salivary gland cancer and corresponding lymph node metastases and represents an important treatment-related biomarker.

IF 4.2 3区 医学 Q2 ONCOLOGY
Clinical & Experimental Metastasis Pub Date : 2023-10-01 Epub Date: 2023-07-22 DOI:10.1007/s10585-023-10222-w
Marcel Mayer, Lisa Nachtsheim, Johanna Prinz, Sami Shabli, Malte Suchan, Jens Peter Klußmann, Alexander Quaas, Christoph Arolt, Philipp Wolber
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引用次数: 0

Abstract

Many locally advanced and metastatic salivary gland carcinomas (SGC) lack therapeutic targets. Enfortumab vedotin, an antibody-drug conjugate binding to Nectin-4, recently gained FDA approval for third-line urothelial carcinoma. Therefore, the aim of this study was to assess the expression of Nectin-4 in primary SGC and corresponding lymph node metastases and to correlate it with clinicopathological data. Immunohistochemical staining for Nectin-4 was performed for patients who had undergone surgery with curative intent for primary SGC of the parotid or submandibular gland in a tertiary referral center between 1990 and 2019. One hundred twenty-two primary SGC and twenty corresponding lymph node metastases were included. Nectin-4 was expressed in 80.3% of primary SGC with a mean Histo(H-)score of 61.2 and in 90.0% of lymph node metastases with a mean H-score of 75.6. A moderate or high Nectin-4 expression was found in 25.9% of salivary duct carcinomas (SaDu) and in 30.7% of adenoid cystic carcinomas (ACC). SaDu patients with a lower T-stage (p = 0.04), no loco-regional lymph node metastases (p = 0.049), no vascular invasion (p = 0.04), and no perineural spread (p = 0.03) showed a significantly higher mean Nectin-4 H-score. There was a statistical tendency towards a more favorable disease-free survival among SaDu patients with a higher Nectin-4 expression (p = 0.09). Nectin-4 is expressed in SGC and therefore represents a potential therapeutic target, especially in entities with a high rate of local recurrence and metastatic spread such as SaDu and ACC.

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Nectin-4在原发性唾液腺癌症和相应的淋巴结转移中频繁表达,是一种重要的治疗相关生物标志物。
许多局部晚期和转移性唾液腺癌(SGC)缺乏治疗靶点。Enfortumab vedotin是一种与Nectin-4结合的抗体-药物偶联物,最近获得了美国食品药品监督管理局对三线尿路上皮癌的批准。因此,本研究的目的是评估Nectin-4在原发性SGC和相应淋巴结转移中的表达,并将其与临床病理数据相关联。1990年至2019年间,在一家三级转诊中心为治疗腮腺或下颌下腺原发性SGC而接受手术的患者进行了Nectin-4的免疫组织化学染色。包括122例原发性SGC和20例相应的淋巴结转移。Nectin-4在80.3%的原发性SGC中表达,其平均Histo(H-)评分为61.2,在90.0%的淋巴结转移中表达,平均H-评分为75.6。在25.9%的唾液管癌(SaDu)和30.7%的腺样囊性癌(ACC)中发现中等或高表达的Nectin-4。SaDu患者T分期较低(p = 0.04),无局部淋巴结转移(p = 0.049),无血管侵犯(p = 0.04),无神经性扩张(p = 0.03)显示出显著更高的平均Nectin-4 H-核心。在Nectin-4表达较高的SaDu患者中,有更有利的无病生存率的统计学趋势(p = 0.09)。Nectin-4在SGC中表达,因此代表了一个潜在的治疗靶点,特别是在具有高局部复发率和转移性扩散的实体中,如SaDu和ACC。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.80
自引率
5.00%
发文量
55
审稿时长
12 months
期刊介绍: The Journal''s scope encompasses all aspects of metastasis research, whether laboratory-based, experimental or clinical and therapeutic. It covers such areas as molecular biology, pharmacology, tumor biology, and clinical cancer treatment (with all its subdivisions of surgery, chemotherapy and radio-therapy as well as pathology and epidemiology) insofar as these disciplines are concerned with the Journal''s core subject of metastasis formation, prevention and treatment.
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