{"title":"Bioactive PI3-kinase/Akt/mTOR Inhibitors in Targeted Lung Cancer Therapy.","authors":"Somayyeh Ghareghomi, Vahideh Atabaki, Naseh Abdollahzadeh, Shahin Ahmadian, Salar Hafez Ghoran","doi":"10.34172/apb.2023.003","DOIUrl":null,"url":null,"abstract":"<p><p>One of the central signaling pathways with a regulatory effect on cell proliferation and survival is Akt/mTOR. In many human cancer types, for instance, lung cancer, the overexpression of Akt/mTOR has been reported. For this reason, either targeting cancer cells by synthetic or natural products affecting the Akt/mTOR pathway down-regulation is a useful strategy in cancer therapy. Direct inhibition of the signaling pathway or modulation of each related molecule could have significant feedback on the growth and proliferation of cancer cells. A variety of secondary metabolites has been identified to directly inhibit the AKT/mTOR signaling, which is important in the field of drug discovery. Naturally occurring nitrogenous and phenolic compounds can emerge as two pivotal classes of natural products possessing anticancer abilities. Herein, we have summarized the alkaloids and flavonoids for lung cancer treatment together with all the possible mechanisms of action relying on the Akt/mTOR pathway down-regulation. This review suggested that in search of new drugs, phytochemicals could be considered as promising scaffolds to be developed into efficient drugs for the treatment of cancer. In this review, the terms \"Akt/mTOR\", \"Alkaloid\", \"flavonoid\", and \"lung cancer\" were searched without any limitation in search criteria in Scopus, PubMed, Web of Science, and Google scholar engines.</p>","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"13 1","pages":"24-35"},"PeriodicalIF":3.1000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871280/pdf/","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced pharmaceutical bulletin","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34172/apb.2023.003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 2
Abstract
One of the central signaling pathways with a regulatory effect on cell proliferation and survival is Akt/mTOR. In many human cancer types, for instance, lung cancer, the overexpression of Akt/mTOR has been reported. For this reason, either targeting cancer cells by synthetic or natural products affecting the Akt/mTOR pathway down-regulation is a useful strategy in cancer therapy. Direct inhibition of the signaling pathway or modulation of each related molecule could have significant feedback on the growth and proliferation of cancer cells. A variety of secondary metabolites has been identified to directly inhibit the AKT/mTOR signaling, which is important in the field of drug discovery. Naturally occurring nitrogenous and phenolic compounds can emerge as two pivotal classes of natural products possessing anticancer abilities. Herein, we have summarized the alkaloids and flavonoids for lung cancer treatment together with all the possible mechanisms of action relying on the Akt/mTOR pathway down-regulation. This review suggested that in search of new drugs, phytochemicals could be considered as promising scaffolds to be developed into efficient drugs for the treatment of cancer. In this review, the terms "Akt/mTOR", "Alkaloid", "flavonoid", and "lung cancer" were searched without any limitation in search criteria in Scopus, PubMed, Web of Science, and Google scholar engines.
Akt/mTOR是调控细胞增殖和存活的主要信号通路之一。在许多人类癌症类型中,例如肺癌,Akt/mTOR的过度表达已被报道。因此,通过影响Akt/mTOR通路下调的合成或天然产物靶向癌细胞是一种有效的癌症治疗策略。直接抑制信号通路或调节各相关分子对癌细胞的生长和增殖有显著的反馈作用。多种次生代谢物可直接抑制AKT/mTOR信号传导,这在药物研发领域具有重要意义。天然存在的氮化合物和酚类化合物可以作为具有抗癌能力的两类关键天然产物出现。在此,我们总结了生物碱和黄酮类化合物治疗肺癌的作用,以及依赖于Akt/mTOR通路下调的所有可能的作用机制。这一综述表明,在寻找新的药物的过程中,植物化学物质可以被认为是一个有前途的支架,可以开发成有效的治疗癌症的药物。在本文中,我们在Scopus、PubMed、Web of Science和Google学术搜索引擎中对“Akt/mTOR”、“Alkaloid”、“flavonoids”和“lung cancer”等关键词进行了检索,检索条件不受任何限制。