Association between the Putative Meningeal Lymphatics at the Posterior Wall of the Sigmoid Sinus and Delayed Contrast-agent Elimination from the Cerebrospinal Fluid.

IF 2.5 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance in Medical Sciences Pub Date : 2024-01-01 Epub Date: 2023-01-19 DOI:10.2463/mrms.mp.2022-0110

Shinji Naganawa, Rintaro Ito, Mariko Kawamura, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone

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引用次数: 0

Abstract

Purpose: To investigate the characteristics of the putative meningeal lymphatics located at the posterior wall of the sigmoid sinus (PML-PSS) in human subjects imaged before and after intravenous administration (IV) of a gadolinium-based contrast agent (GBCA). The appearance of the PML-PSS and the enhancement of the perivascular space of the basal ganglia (PVS-BG) were analyzed for an association with gender, age, and clearance of the GBCA from the cerebrospinal fluid (CSF).

Methods: Forty-two patients with suspected endolymphatic hydrops were included. Heavily T2-weighted 3D-fluid attenuated inversion recovery (hT2w-3D-FLAIR) and 3D-real inversion recovery (IR) images were obtained at pre-administration, immediately post-administration, and at 4 and 24 hours after IV-GBCA. The appearance of the PML-PSS and the presence of enhancement in the PVS-BG were analyzed for a relationship with age, gender, contrast enhancement of the CSF at 4 hours after IV-GBCA, and the washout ratio of the GBCA in the CSF from 4 to 24 hours after IV-GBCA.

Results: The PML-PSS and PVS-BG were seen in 23 of 42 and 21 of 42 cases, respectively, at 4 hours after IV-GBCA. In all PML-PSS positive cases, hT2w-3D-FLAIR signal enhancement was highest at 4 hours after IV-GBCA. A multivariate analysis between gender, age, CSF signal elevation at 4 hours, and washout ratio indicated that only the washout ratio was independently associated with the enhancement of the PML-PSS or PVS-BG. The odds ratios (95% CIs; P value) were 4.09 × 10^-5 (2.39 × 10^-8 - 0.07; 0.0078) for the PML-PSS and 1.7 × 10^-4 (1.66 × 10^-7 - 0.174; 0.014) for the PVS-BG.

Conclusion: The PML-PSS had the highest signal enhancement at 4 hours after IV-GBCA. When the PML-PSS was seen, there was also often enhancement of the PVS-BG at 4 hours after IV-GBCA. Both observed enhancements were associated with delayed GBCA excretion from the CSF.

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乙状结肠窦后壁的假定脑膜淋巴管与脑脊液中对比剂的延迟清除之间的联系

目的：研究在静脉注射钆基造影剂（GBCA）前后成像的人类受试者中，位于乙状窦后壁（PML-PSS）的假定脑膜淋巴管的特征。分析了 PML-PSS 的外观和基底节血管周围空间（PVS-BG）的增强与性别、年龄和脑脊液（CSF）中 GBCA 的清除率之间的关系：方法：纳入 42 例疑似内淋巴水肿患者。在给药前、给药后、静脉注射 GBCA 后 4 小时和 24 小时分别获得高 T2 加权三维流体衰减反转恢复（hT2w-3D-FLAIR）和三维真实反转恢复（IR）图像。分析了 PML-PSS 的出现和 PVS-BG 的增强与年龄、性别、静脉注射 GBCA 后 4 小时 CSF 的对比度增强以及静脉注射 GBCA 后 4 至 24 小时 CSF 中 GBCA 的洗脱率之间的关系：静脉注射 GBCA 后 4 小时，42 例病例中分别有 23 例和 21 例出现 PML-PSS 和 PVS-BG。在所有PML-PSS阳性病例中，IV-GBCA术后4小时hT2w-3D-FLAIR信号增强最高。性别、年龄、4 小时时 CSF 信号升高和冲洗比之间的多变量分析表明，只有冲洗比与 PML-PSS 或 PVS-BG 的增强独立相关。PML-PSS的几率（95% CIs; P值）为4.09 × 10-5 (2.39 × 10-8 - 0.07; 0.0078)，PVS-BG的几率（95% CIs; P值）为1.7 × 10-4 (1.66 × 10-7 - 0.174; 0.014)：结论：PML-PSS在IV-GBCA后4小时的信号增强最高。结论：在静脉注射 GBCA 后 4 小时，PML-PSS 的信号增强最高，PVS-BG 在静脉注射 GBCA 后 4 小时也经常出现增强。观察到的这两种增强都与 GBCA 从 CSF 中排泄的延迟有关。

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来源期刊

Magnetic Resonance in Medical Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

5.80

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： Magnetic Resonance in Medical Sciences (MRMS or Magn Reson Med Sci) is an international journal pursuing the publication of original articles contributing to the progress of magnetic resonance in the field of biomedical sciences including technical developments and clinical applications. MRMS is an official journal of the Japanese Society for Magnetic Resonance in Medicine (JSMRM).