Bridging live-cell imaging and next-generation cancer treatment

IF 72.5 1区医学 Q1 ONCOLOGY

Nature Reviews Cancer Pub Date : 2023-09-13 DOI:10.1038/s41568-023-00610-5

Maria Alieva, Amber K. L. Wezenaar, Ellen J. Wehrens, Anne C. Rios

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Abstract

By providing spatial, molecular and morphological data over time, live-cell imaging can provide a deeper understanding of the cellular and signalling events that determine cancer response to treatment. Understanding this dynamic response has the potential to enhance clinical outcome by identifying biomarkers or actionable targets to improve therapeutic efficacy. Here, we review recent applications of live-cell imaging for uncovering both tumour heterogeneity in treatment response and the mode of action of cancer-targeting drugs. Given the increasing uses of T cell therapies, we discuss the unique opportunity of time-lapse imaging for capturing the interactivity and motility of immunotherapies. Although traditionally limited in the number of molecular features captured, novel developments in multidimensional imaging and multi-omics data integration offer strategies to connect single-cell dynamics to molecular phenotypes. We review the effect of these recent technological advances on our understanding of the cellular dynamics of tumour targeting and discuss their implication for next-generation precision medicine. Live-cell imaging can provide spatial, morphological and molecular understanding of cancer response to treatment. Here, Alieva et al. review its recent application for uncovering drug mode of action and tumour heterogeneity in response to treatment and discuss its application for next-generation precision medicine.

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桥接活细胞成像和下一代癌症治疗。

通过提供随时间变化的空间、分子和形态学数据，活细胞成像可以更深入地了解决定癌症治疗反应的细胞和信号事件。了解这种动态反应有可能通过识别生物标志物或可操作的靶点来提高治疗效果，从而提高临床结果。在此，我们回顾了活细胞成像在揭示治疗反应中的肿瘤异质性和癌症靶向药物作用模式方面的最新应用。鉴于T细胞疗法的使用越来越多，我们讨论了延时成像捕捉免疫疗法的互动性和运动性的独特机会。尽管传统上捕获的分子特征数量有限，但多维成像和多组学数据整合的新发展提供了将单细胞动力学与分子表型联系起来的策略。我们回顾了这些最新技术进步对我们理解肿瘤靶向的细胞动力学的影响，并讨论了它们对下一代精准医学的意义。

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来源期刊

Nature Reviews Cancer 医学-肿瘤学

CiteScore

111.90

自引率

0.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.