Drawing a line?-Visuo-constructive function as discriminator between healthy individuals, subjective cognitive decline, mild cognitive impairment and Alzheimer's disease and predictor of disease progress compared to a multimodal approach.

IF 1.1 Q4 PSYCHIATRY

NEUROPSYCHIATRIE Pub Date : 2024-06-01 Epub Date: 2023-02-01 DOI:10.1007/s40211-022-00455-8

Amelie Tokaj, Johann Lehrner

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引用次数: 0

Abstract

Purpose: One cognitive domain impaired in Alzheimer's disease (AD) is visuo-construction. The Vienna Visuo-constructional Test 3.0 Screening (VVT 3.0 Screening) measures this cognitive domain. This study examines how it works in the differentiation of AD from healthy controls (HC) and the prodromal stages subjective cognitive decline (SCD) and mild cognitive impairment (MCI) and also how it performs in prediction of progress compared to the Mini Mental State Examination (MMSE) and the Sunderland Clock Drawing Test (CDT).

Methods: Data from 622 patients (33 HC, 68 SCD, 301 MCI, 220 AD) who completed all three tests were obtained. Furthermore, 117 patients were examined in a follow-up. Data were analyzed in a retrospective analysis comparing the validity of tests in diagnosis and prediction using receiver operator characteristic (ROC) curves and multinominal logistic regression.

Results: The VVT 3.0 Screening shows some ability to discriminate between AD and all other participants (sensitivity: 62.1%, specificity: 83.1%), while of the three examined tests none was able to predict membership to all experimental groups or to predict disease-progress adequately. As the VVT 3.0 Screening is short, easy to apply and largely language independent, it can be considered an alternative to the MMSE in certain situations.

Conclusions: The VVT 3.0 Screening is useful to discriminate between AD and all other participants and can be an alternative to the MMSE in certain situations.

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与多模态方法相比，"划清界限"--视构图功能是区分健康人、主观认知功能衰退、轻度认知功能障碍和阿尔茨海默病的指标，也是疾病进展的预测指标。

目的：阿尔兹海默病（AD）的一个认知领域是视觉建构。维也纳视觉结构测试 3.0 筛选（VVT 3.0 筛选）可测量这一认知领域。本研究探讨了该测试在区分注意力缺失症（AD）与健康对照组（HC）、前驱期主观认知功能减退（SCD）和轻度认知功能障碍（MCI）方面的作用，以及与迷你精神状态检查（MMSE）和桑德兰时钟绘图测试（CDT）相比，该测试在预测病情进展方面的表现：方法：获得了完成所有三项测试的 622 名患者（33 名高血压患者、68 名轻度脑损伤患者、301 名轻度脑损伤患者、220 名中度脑损伤患者）的数据。此外，还对 117 名患者进行了随访。在一项回顾性分析中对数据进行了分析，利用接收器操作特征曲线（ROC）和多项式逻辑回归比较了测试在诊断和预测中的有效性：VVT 3.0筛查显示了一定的区分AD和所有其他参与者的能力（灵敏度：62.1%，特异性：83.1%），而在三项检测中，没有一项能预测所有实验组的成员或充分预测疾病的进展。由于 VVT 3.0 筛选简短、易于使用且基本不受语言影响，因此在某些情况下可被视为 MMSE 的替代方法：结论：VVT 3.0 筛选可用于区分注意力缺失症和所有其他参与者，在某些情况下可替代 MMSE。

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来源期刊

NEUROPSYCHIATRIE PSYCHIATRY-

CiteScore

3.80

自引率

20.00%

发文量

期刊介绍： Die Zeitschrift ist das offizielle Organ der „Österreichischen Gesellschaft für Psychiatrie, Psychotherapie und Psychosomatik (ÖGPP)'', und wissenschaftliches Organ der Österreichischen Alzheimer Gesellschaft, der Österreichischen Gesellschaft für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie, der Österreichischen Schizophreniegesellschaft, und der pro mente austria - Österreichischer Dachverband der Vereine und Gesellschaften für psychische und soziale Gesundheit.Sie veröffentlicht Übersichten zu relevanten Themen des Fachs, Originalarbeiten, Kasuistiken sowie Briefe an die Herausgeber. Zudem wird auch Buchbesprechungen sowie Neuigkeiten aus den Bereichen Personalia, Standes- und Berufspolitik sowie Kongressankündigungen Raum gewidmet.Thematisch ist das Fach Psychiatrie und die Methoden der Psychotherapie in allen ihren Facetten vertreten. Die Zeitschrift richtet sich somit an alle Berufsgruppen, die sich mit Ursachen, Erscheinungsformen und Behandlungsmöglichkeiten von psychischen Störungen beschäftigen. -----------------------------------------------------------------------------------------------------· The professional and educational journal of the Austrian Society of Psychiatry, Psychotherapy and Psychosomatics (Österreichische Gesellschaft für Psychiatrie, Psychotherapie und Psychosomatik; ÖGPP) and the Austrian Society of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy (Österreichische Gesellschaft für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie; ÖGKJP)· Overviews of all relevant topics pertaining to the discipline· Intended for all occupational groups committed to the causes and manifestations of, as well as therapy options for psychic disorders· All manuscripts principally pass through a double-blind peer review process involving at least two independent expertsThe official journal of the Austrian Societies of Psychiatry, Psychotherapy and Psychosomatics (ÖGPP) and Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy (ÖGKJP)The journal publishes overviews of relevant issues in the field, original work, case reports and letters to the editors. In addition, space is devoted to book reviews, news from the areas of personnel matters and professional policies, and conference announcements.Thematically, the discipline of psychiatry and the methods of psychotherapy are represented in all their facets. The journal is thus aimed at all professional groups committed to the causes and manifestations of, as well as therapy options for psychic disorders