Does molecular scarring in psoriasis exist? A review of the literature.

IF 1.4 4区 医学 Q3 ALLERGY
Marta Kasprowicz-Furmańczyk, Joanna Narbutt, Adam Borzęcki, Agnieszka Owczarczyk-Saczonek
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引用次数: 0

Abstract

Plaque psoriasis is a chronic inflammatory dermatosis characterized by a tendency to recur in the same locations after discontinuation of treatment. The implementation of therapy with drugs targeting cytokines like interleukin (IL) 17A (IL-17A) and IL-23 has revolutionized the treatment of psoriasis and enabled the achievement of skin without lesions. However, despite the clinical resolution of psoriatic eruptions, cells that maintain the local memory of the disease remain in the dermis and epidermis, constituting a kind of molecular scar. The cells responsible for maintaining memory in the skin of patients and influencing the rapid relapse of the disease after the triggering factor are primarily tissue resident memory T cells (TRM), but it seems that regulatory T lymphocytes (Treg), dendritic cells (DC), and Langerhans cells (LC) may also play an important role in this process. We reviewed the literature to explain the concept of molecular scarring in psoriasis, and to assess the effect of various therapies on immune memory.

Abstract Image

银屑病分子瘢痕存在吗?文献综述。
斑块型银屑病是一种慢性炎症性皮肤病,其特点是在停止治疗后在同一部位复发。针对白细胞介素(IL) 17A (IL-17A)和IL-23等细胞因子的药物治疗的实施彻底改变了银屑病的治疗方法,使皮肤无损伤成为可能。然而,尽管银屑病疹的临床消退,维持疾病局部记忆的细胞仍留在真皮和表皮中,构成一种分子疤痕。患者皮肤中负责维持记忆并影响触发因子后疾病快速复发的细胞主要是组织常驻记忆T细胞(TRM),但似乎调节性T淋巴细胞(Treg)、树突状细胞(DC)和朗格汉斯细胞(LC)也可能在这一过程中发挥重要作用。我们回顾文献来解释银屑病分子瘢痕的概念,并评估各种治疗对免疫记忆的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.60
自引率
7.10%
发文量
107
审稿时长
6-12 weeks
期刊介绍: Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii is a bimonthly aimed at allergologists and dermatologists.
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