Item Selection for a New Health-Related Quality of Life Measure for Parkinson's Disease: The Preference-Based Parkinson's Disease Index (PB-PDI).

IF 1.7 Q4 NEUROSCIENCES
Selina Malouka, Lizabeth Teshler, Nancy Mayo, Marla Beauchamp, Julie Richardson, Ayse Kuspinar
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引用次数: 0

Abstract

Background Parkinson's disease (PD) is a neurodegenerative condition, predominantly affecting older adults. Preference-based measures (PBMs) can be used to make decisions about the cost-utility of different treatments. There are currently no PBMs for health-related quality of life (HRQoL) for PD. A previous study identified important health domains for individuals with PD and developed an item pool from existing measures per domain. The current study aims to contribute to the development of a new disease-specific PBM of HRQoL for PD by reducing the current pool of items according to the preferences of individuals with PD. Methods Fifty-three participants completed a visual analogue scale (VAS) of self-perceived health, the prototype PBM measure, and an item importance rating. To reduce the item pool, the following were calculated: (1) inter-item correlations; (2) impact of each item based on item performance and importance rating; (3) directionality of response options by comparing the VAS scores against each item. Results Participants (male = 54.7%, age = 60.0 ± 10.2) had a median Hoehn and Yahr score of 2.5 (interquartile range = 1). Items supported for inclusion by this analysis were sleep, fatigue, tremor, mood, walking, memory, and dexterity. Items demonstrating a logical decrease in VAS score with each increasing severity level were sleep, memory, tremor, fatigue, and mood. Conclusion This PBM will be critical for informing decisions about the cost-utility of PD treatments, guiding the resource allocation within our healthcare system. Future research will include cognitive debriefing with individuals with PD to refine item response options.
帕金森病新的健康相关生活质量测量的项目选择:基于偏好的帕金森病指数(PB-PDI)
背景:帕金森病(PD)是一种神经退行性疾病,主要影响老年人。基于偏好的措施(PBMs)可用于决定不同治疗的成本效用。目前还没有针对PD的健康相关生活质量(HRQoL)的PBMs。先前的一项研究确定了PD患者的重要健康领域,并从每个领域的现有测量中开发了一个项目池。本研究旨在根据PD患者的偏好减少现有的项目库,从而促进PD HRQoL的新疾病特异性PBM的发展。方法:53名被试完成了自我感知健康的视觉模拟量表(VAS)、原型PBM测量和项目重要性评定。为了减少项目池,计算如下:(1)项目间相关性;(2)基于项目性能和重要性评级的每个项目的影响;(3)通过比较VAS评分对各项目的反应选项的方向性。结果:参与者(男性= 54.7%,年龄= 60.0±10.2)的Hoehn和Yahr评分中位数为2.5(四分位数间距= 1)。该分析支持纳入的项目包括睡眠、疲劳、震颤、情绪、行走、记忆和灵活性。VAS评分随严重程度的增加而下降的项目有睡眠、记忆、震颤、疲劳和情绪。结论:该PBM将对PD治疗的成本-效用决策至关重要,指导我们医疗系统内的资源分配。未来的研究将包括对PD患者进行认知汇报,以完善项目反应选项。
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来源期刊
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
17 weeks
期刊介绍: Neurology Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focusing on diseases of the nervous system, as well as normal neurological functioning. The journal will consider basic, translational, and clinical research, including animal models and clinical trials.
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