Scavengome of an antioxidant.

4区医学 Q3 Biochemistry, Genetics and Molecular Biology

Vitamins and Hormones Pub Date : 2023-01-01 DOI:10.1016/bs.vh.2022.09.003

Attila Hunyadi, Orinhamhe G Agbadua, Gábor Takács, Gyorgy T Balogh

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引用次数: 1

Abstract

The term "scavengome" refers to the chemical space of all the metabolites that may be formed from an antioxidant upon scavenging reactive oxygen or nitrogen species (ROS/RNS). This chemical space covers a wide variety of free radical metabolites with drug discovery potential. It is very rich in structures representing an increased chemical complexity as compared to the parent antioxidant: a wide range of unusual heterocyclic structures, new CC bonds, etc. may be formed. Further, in a biological environment, this increased chemical complexity is directly translated from the localized conditions of oxidative stress that determines the amounts and types of ROS/RNS present. Biomimetic oxidative chemistry provides an excellent tool to model chemical reactions between antioxidants and ROS/RNS. In this chapter, we provide an overview on the known metabolites obtained by biomimetic oxidation of a few selected natural antioxidants, i.e., a stilbene (resveratrol), a pair of hydroxycinnamates (caffeic acid and methyl caffeate), and a flavonol (quercetin), and discuss the drug discovery perspectives of the related chemical space.

查看原文本刊更多论文

抗氧化剂的清道夫。

术语“清除组”是指抗氧化剂在清除活性氧或活性氮(ROS/RNS)时可能形成的所有代谢物的化学空间。这个化学空间涵盖了各种具有药物发现潜力的自由基代谢物。与母体抗氧化剂相比，它具有丰富的结构，具有更高的化学复杂性:可以形成各种不同寻常的杂环结构，新的CC键等。此外，在生物环境中，这种增加的化学复杂性直接来自于氧化应激的局部条件，氧化应激决定了存在的ROS/RNS的数量和类型。仿生氧化化学为模拟抗氧化剂与ROS/RNS之间的化学反应提供了一个很好的工具。在本章中，我们概述了几种天然抗氧化剂通过仿生氧化获得的已知代谢物，即二苯乙烯(白藜芦醇)，一对羟基肉桂酸(咖啡酸和咖啡酸甲酯)和黄酮醇(槲皮素)，并讨论了相关化学领域的药物发现前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vitamins and Hormones 医学-内分泌学与代谢

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.