Nerve growth factor and angiotensin converting enzyme 2 levels in children with neurodevelopmental disorders.

IF 1.7 4区医学 Q4 NEUROSCIENCES

International Journal of Neuroscience Pub Date : 2024-11-01 Epub Date: 2023-09-13 DOI:10.1080/00207454.2023.2257871

Melike Kevser Gul, Murside Sahin, Esra Demirci, Sevgi Ozmen, Reyhan Tahtasakal, Elif Funda Sener

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引用次数: 0

Abstract

Objective: Neurodevelopmental disorders (NDDs) are the most common psychiatric disorders in childhood, and there are many factors in their etiology. In recent years, many biomarkers have been studied to elucidate the etiology of these disorders. In this study, it was aimed to investigate the levels of nerve growth factor (NGF) and angiotensin converting enzyme 2 (ACE2) in attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and intellectual disability (ID).

Methods: The study included 74 children with NDDs (the number of patients in ADHD, ASD and ID groups were 24, 25 and 25 respectively) and 30 healthy controls (HCs). Serum NGF and ACE2 levels were studied with ELISA kits, also complete blood count (CBC), levels of fasting glucose and serum lipids were assessed.

Results: ACE2 levels were found to be lower in NDD group than HCs in girls. In boys with ASD, triglyceride levels were significantly higher than other groups. Also a positive correlation was found between ACE2 and NGF levels when all sample assessed together.

Conclusions: This study is a premise for investigating ACE2 and NGF in NDDs. The role of these markers in ADHD, ASD, ID and other NDDs and their associations with gender should be assessed by studies in which both larger sample groups and more disorders.

查看原文本刊更多论文

神经发育障碍患儿的神经生长因子和血管紧张素转换酶2水平。

目的：神经发育障碍（ndd）是儿童时期最常见的精神障碍，其病因是多方面的。近年来，人们研究了许多生物标志物来阐明这些疾病的病因。本研究旨在探讨神经生长因子（NGF）和血管紧张素转换酶2 （ACE2）在注意缺陷多动障碍（ADHD）、自闭症谱系障碍（ASD）和智力残疾（ID）患者中的水平。方法：纳入74例ndd患儿（ADHD组24例，ASD组25例，ID组25例）和30例健康对照（hc）。ELISA试剂盒检测血清NGF和ACE2水平，同时检测全血细胞计数（CBC）、空腹血糖和血脂水平。结果：女孩NDD组ACE2水平低于hc组。在患有自闭症谱系障碍的男孩中，甘油三酯水平明显高于其他组。当所有样本一起评估时，也发现ACE2和NGF水平呈正相关。结论：本研究为探究ndd中ACE2和NGF的作用提供了前提。这些标记物在ADHD、ASD、ID和其他ndd中的作用及其与性别的关联应该通过更大样本组和更多疾病的研究来评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Neuroscience 医学-神经科学

CiteScore

5.10

自引率

0.00%

发文量

132

审稿时长

2 months

期刊介绍： The International Journal of Neuroscience publishes original research articles, reviews, brief scientific reports, case studies, letters to the editor and book reviews concerned with problems of the nervous system and related clinical studies, epidemiology, neuropathology, medical and surgical treatment options and outcomes, neuropsychology and other topics related to the research and care of persons with neurologic disorders. The focus of the journal is clinical and transitional research. Topics covered include but are not limited to: ALS, ataxia, autism, brain tumors, child neurology, demyelinating diseases, epilepsy, genetics, headache, lysosomal storage disease, mitochondrial dysfunction, movement disorders, multiple sclerosis, myopathy, neurodegenerative diseases, neuromuscular disorders, neuropharmacology, neuropsychiatry, neuropsychology, pain, sleep disorders, stroke, and other areas related to the neurosciences.