Effect of transcranial direct current stimulation on learning in older adults with and without Parkinson’s disease: A systematic review with meta-analysis

IF 2.2 3区心理学 Q3 NEUROSCIENCES

Brain and Cognition Pub Date : 2023-10-01 DOI:10.1016/j.bandc.2023.106073

Britt Vandendoorent , Evelien Nackaerts , Demi Zoetewei , Femke Hulzinga , Moran Gilat , Jean-Jacques Orban de Xivry , Alice Nieuwboer

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引用次数: 0

Abstract

Older adults with and without Parkinson’s disease show impaired retention after training of motor or cognitive skills. This systematic review with meta-analysis aims to investigate whether adding transcranial direct current stimulation (tDCS) to motor or cognitive training versus placebo boosts motor sequence and working memory training. The effects of interest were estimated between three time points, i.e. pre-training, post-training and follow-up. This review was conducted according to the PRISMA guidelines (PROSPERO: CRD42022348885). Electronic databases were searched from conception to March 2023. Following initial screening, 24 studies were eligible for inclusion in the qualitative synthesis and 20 could be included in the meta-analysis, of which 5 studies concerned motor sequence learning (total n = 186) and 15 working memory training (total n = 650). Results were pooled using an inverse variance random effects meta-analysis. The findings showed no statistically significant additional effects of tDCS over placebo on motor sequence learning outcomes. However, there was a strong trend showing that tDCS boosted working memory training, although methodological limitations and some heterogeneity were also apparent. In conclusion, the present findings do not support wide implementation of tDCS as an add-on to motor sequence training at the moment, but the promising results on cognitive training warrant further investigations.

查看原文本刊更多论文

经颅直流电刺激对患有和不患有帕金森病的老年人学习的影响：一项荟萃分析系统综述。

患有和不患有帕金森氏症的老年人在运动或认知技能训练后表现出记忆力受损。这项荟萃分析系统综述旨在调查与安慰剂相比，在运动或认知训练中加入经颅直流电刺激（tDCS）是否能促进运动序列和工作记忆训练。兴趣的影响是在三个时间点之间估计的，即训练前、训练后和随访。该审查是根据PRISMA指南（PROSPERO:CD402234885）进行的。检索了从受孕到2023年3月的电子数据库。初步筛选后，有24项研究符合纳入定性综合的条件，20项研究可纳入荟萃分析，其中5项研究涉及运动序列学习（总数n=186），15项研究涉及工作记忆训练（总数n=650）。使用反向方差随机效应荟萃分析汇总结果。研究结果显示，与安慰剂相比，tDCS对运动序列学习结果没有统计学意义的额外影响。然而，有一个强烈的趋势表明，tDCS促进了工作记忆训练，尽管方法上的局限性和一些异质性也很明显。总之，目前的研究结果并不支持将tDCS作为运动序列训练的附加项进行广泛实施，但认知训练的良好结果值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain and Cognition 医学-神经科学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Brain and Cognition is a forum for the integration of the neurosciences and cognitive sciences. B&C publishes peer-reviewed research articles, theoretical papers, case histories that address important theoretical issues, and historical articles into the interaction between cognitive function and brain processes. The focus is on rigorous studies of an empirical or theoretical nature and which make an original contribution to our knowledge about the involvement of the nervous system in cognition. Coverage includes, but is not limited to memory, learning, emotion, perception, movement, music or praxis in relationship to brain structure or function. Published articles will typically address issues relating some aspect of cognitive function to its neurological substrates with clear theoretical import, formulating new hypotheses or refuting previously established hypotheses. Clinical papers are welcome if they raise issues of theoretical importance or concern and shed light on the interaction between brain function and cognitive function. We welcome review articles that clearly contribute a new perspective or integration, beyond summarizing the literature in the field; authors of review articles should make explicit where the contribution lies. We also welcome proposals for special issues on aspects of the relation between cognition and the structure and function of the nervous system. Such proposals can be made directly to the Editor-in-Chief from individuals interested in being guest editors for such collections.