Salicylic acids and pathogenic bacteria: new perspectives on an old compound.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 Epub Date: 2023-09-12 DOI:10.1139/cjm-2023-0123

Ellen M E Sykes, Dawn White, Sydney McLaughlin, Ayush Kumar

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引用次数: 0

Abstract

Salicylic acids have been used in human and veterinary medicine for their anti-pyretic, anti-inflammatory, and analgesic properties for centuries. A key role of salicylic acid-immune modulation in response to microbial infection-was first recognized during studies of their botanical origin. The effects of salicylic acid on bacterial physiology are diverse. In many cases, they impose selective pressures leading to development of cross-resistance to antimicrobial compounds. Initial characterization of these interactions was in Escherichia coli, where salicylic acid activates the multiple antibiotic resistance (mar) operon, resulting in decreased antibiotic susceptibility. Studies suggest that stimulation of the mar phenotype presents similarly in closely related Enterobacteriaceae. Salicylic acids also affect virulence in many opportunistic pathogens by decreasing their ability to form biofilms and increasing persister cell populations. It is imperative to understand the effects of salicylic acid on bacteria of various origins to illuminate potential links between environmental microbes and their clinically relevant antimicrobial-resistant counterparts. This review provides an update on known effects of salicylic acid and key derivatives on a variety of bacterial pathogens, offers insights to possible potentiation of current treatment options, and highlights cellular regulatory networks that have been established during the study of this important class of medicines.

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水杨酸和致病菌：一种古老化合物的新视角。

几个世纪以来，水杨酸因其解热、抗炎和镇痛特性而被用于人类和兽医。水杨酸在应对微生物感染中的免疫调节的关键作用在其植物来源的研究中首次被认识到。水杨酸对细菌生理的影响是多种多样的。在许多情况下，它们施加选择性压力，导致对抗菌化合物产生交叉耐药性。这些相互作用的初步特征是在大肠杆菌中，水杨酸激活了多重抗生素耐药性（mar）操纵子，导致抗生素易感性降低。研究表明，mar表型的刺激在密切相关的肠杆菌科中表现相似。水杨酸还通过降低其形成生物膜的能力和增加持久性细胞群来影响许多机会性病原体的毒力。必须了解水杨酸对各种来源细菌的影响，以阐明环境微生物与其临床相关抗微生物耐药性对应物之间的潜在联系。这篇综述提供了水杨酸及其关键衍生物对各种细菌病原体的已知作用的最新情况，深入了解了当前治疗方案的可能增强作用，并强调了在这类重要药物的研究过程中建立的细胞调控网络。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.