Using nutrigenomics to guide personalized nutrition supplementation for bolstering immune system.

IF 4.7 3区医学 Q1 MEDICAL INFORMATICS

Health Information Science and Systems Pub Date : 2023-01-18 eCollection Date: 2023-12-01 DOI:10.1007/s13755-022-00208-5

Jitao Yang

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引用次数: 1

Abstract

Immunity refers to the ability of the human immune system to resist pathogen infection. Immune system has the basic functions of immune defense, immune self stabilization and immune surveillance. Balanced nutrition is the cornerstone of the immune system to play its immune function, and nutritional intervention is also an important means to maintain and improve immunity. Previous studies have confirmed that T cells have individual differences in recognizing viral antigens of virus infected cells, and the body's response to antigens is controlled by a variety of genetic genes, such as human leukocyte antigen (HLA) genes, immune response (Ir) genes, etc. In this paper, through immunity genetic testing, we screen out genetically susceptible people with low immunity and people with the risk of nutrient metabolism disorders; through using lifestyle questionnaire and physical examination results, we analyze people's physical condition, dietary habits, and exercise habits to evaluate people's nutrient deficiency degree. Then, combining multi-dimensional health data, we evaluate users' immune status and nutritional deficiency risk comprehensively, further, we implemented personalized nutrition intervention on the types and doses of nutritional supplements to improve immunity. We also validated the effectiveness of our personalized nutrition solution through a population-based cohort study.

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利用营养基因组学指导个性化营养补充，增强免疫系统。

免疫力是指人体免疫系统抵抗病原体感染的能力。免疫系统具有免疫防御、免疫自我稳定和免疫监视的基本功能。均衡营养是免疫系统发挥免疫功能的基石，营养干预也是维持和提高免疫力的重要手段。先前的研究证实，T细胞在识别病毒感染细胞的病毒抗原方面存在个体差异，身体对抗原的反应由多种遗传基因控制，如人类白细胞抗原（HLA）基因、免疫反应（Ir）基因等，我们筛选出免疫力低的基因易感人群和有营养代谢障碍风险的人群；通过生活方式问卷和体检结果，分析人们的身体状况、饮食习惯和运动习惯，评价人们的营养缺乏程度。然后，结合多维健康数据，全面评估用户的免疫状态和营养缺乏风险，进一步对营养补充剂的类型和剂量进行个性化营养干预，以提高免疫力。我们还通过一项基于人群的队列研究验证了个性化营养解决方案的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Health Information Science and Systems MEDICAL INFORMATICS-

CiteScore

11.30

自引率

5.00%

发文量

期刊介绍： Health Information Science and Systems is a multidisciplinary journal that integrates artificial intelligence/computer science/information technology with health science and services, embracing information science research coupled with topics related to the modeling, design, development, integration and management of health information systems, smart health, artificial intelligence in medicine, and computer aided diagnosis, medical expert systems. The scope includes: i.) smart health, artificial Intelligence in medicine, computer aided diagnosis, medical image processing, medical expert systems ii.) medical big data, medical/health/biomedicine information resources such as patient medical records, devices and equipments, software and tools to capture, store, retrieve, process, analyze, optimize the use of information in the health domain, iii.) data management, data mining, and knowledge discovery, all of which play a key role in decision making, management of public health, examination of standards, privacy and security issues, iv.) development of new architectures and applications for health information systems.