Impact of air pollution on cardiovascular aging

IF 5.3 3区医学 Q2 CELL BIOLOGY

Mechanisms of Ageing and Development Pub Date : 2023-09-01 DOI:10.1016/j.mad.2023.111857

Marin Kuntic , Ivana Kuntic , Omar Hahad , Jos Lelieveld , Thomas Münzel , Andreas Daiber

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引用次数: 1

Abstract

The world population is aging rapidly, and by some estimates, the number of people older than 60 will double in the next 30 years. With the increase in life expectancy, adverse effects of environmental exposures start playing a more prominent role in human health. Air pollution is now widely considered the most detrimental of all environmental risk factors, with some studies estimating that almost 20% of all deaths globally could be attributed to poor air quality. Cardiovascular diseases are the leading cause of death worldwide and will continue to account for the most significant percentage of non-communicable disease burden. Cardiovascular aging with defined pathomechanisms is a major trigger of cardiovascular disease in old age. Effects of environmental risk factors on cardiovascular aging should be considered in order to increase the health span and reduce the burden of cardiovascular disease in older populations. In this review, we explore the effects of air pollution on cardiovascular aging, from the molecular mechanisms to cardiovascular manifestations of aging and, finally, the age-related cardiovascular outcomes. We also explore the distinction between the effects of air pollution on healthy aging and disease progression. Future efforts should focus on extending the health span rather than the lifespan.

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空气污染对心血管老化的影响

世界人口正在迅速老龄化，据估计，60岁以上的人口数量将在未来30年翻一番。随着预期寿命的延长，环境暴露的不利影响开始在人类健康中发挥更加突出的作用。空气污染现在被广泛认为是所有环境风险因素中最有害的，一些研究估计，全球近20%的死亡可归因于空气质量差。心血管疾病是全世界死亡的主要原因，并将继续占非传染性疾病负担的最大比例。具有明确病理机制的心血管老化是老年心血管疾病的主要触发因素。应考虑环境危险因素对心血管老化的影响，以增加老年人群的健康寿命，减轻心血管疾病负担。在这篇综述中，我们探讨了空气污染对心血管衰老的影响，从分子机制到衰老的心血管表现，最后是与年龄相关的心血管结局。我们还探讨了空气污染对健康衰老和疾病进展的影响之间的区别。未来的努力应该集中在延长健康寿命而不是延长寿命。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.