Small interfering RNAs in the management of human osteoporosis.

IF 6.7 2区医学 Q1 Medicine

British medical bulletin Pub Date : 2023-12-11 DOI:10.1093/bmb/ldad023

Giuseppe Gargano, Giovanni Asparago, Filippo Spiezia, Francesco Oliva, Nicola Maffulli

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Abstract

Background: Osteoporosis results in reduced bone mass and consequent bone fragility. Small interfering RNAs (siRNAs) can be used for therapeutic purposes, as molecular targets or as useful markers to test new therapies.

Sources of data: A systematic search of different databases to May 2023 was performed to define the role of siRNAs in osteoporosis therapy. Fourteen suitable studies were identified.

Areas of agreement: SiRNAs may be useful in studying metabolic processes in osteoporosis and identify possible therapeutic targets for novel drug therapies.

Areas of controversy: The metabolic processes of osteoporosis are regulated by many genes and cytokines that can be targeted by siRNAs. However, it is not easy to predict whether the in vitro responses of the studied siRNAs and drugs are applicable in vivo.

Growing points: Metabolic processes can be affected by the effect of gene dysregulation mediated by siRNAs on various growth factors.

Areas timely for developing research: Despite the predictability of pharmacological response of siRNA in vitro, similar responses cannot be expected in vivo.

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小干扰 RNA 在人类骨质疏松症治疗中的应用。

背景：骨质疏松症会导致骨量减少和骨质脆弱。小干扰 RNA（siRNA）可用于治疗目的，作为分子靶标或测试新疗法的有用标记：为了明确 siRNA 在骨质疏松症治疗中的作用，我们对截至 2023 年 5 月的不同数据库进行了系统检索。共找到 14 项合适的研究：SiRNAs可能有助于研究骨质疏松症的代谢过程，并为新型药物疗法确定可能的治疗靶点：骨质疏松症的新陈代谢过程受许多基因和细胞因子的调控，而 siRNAs 可以靶向这些基因和细胞因子。然而，要预测所研究的 siRNA 和药物在体外的反应是否适用于体内并不容易：新陈代谢过程会受到 siRNAs 介导的基因失调对各种生长因子的影响：尽管 siRNA 在体外的药理反应具有可预测性，但不能期望在体内产生类似的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British medical bulletin 医学-医学：内科

CiteScore

13.10

自引率

1.50%

发文量

审稿时长

>12 weeks

期刊介绍： British Medical Bulletin is a multidisciplinary publication, which comprises high quality reviews aimed at generalist physicians, junior doctors, and medical students in both developed and developing countries. Its key aims are to provide interpretations of growing points in medicine by trusted experts in the field, and to assist practitioners in incorporating not just evidence but new conceptual ways of thinking into their practice.