Does the COVID-19 XBB Omicron subvariant signal the beginning of the end of the pandemic?

IF 1.7 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Singapore medical journal Pub Date : 2024-12-01 Epub Date: 2022-12-01 DOI:10.4103/singaporemedj.SMJ-2022-180
Jinghao Nicholas Ngiam, Abdurrahmaan Al-Mubaarak, Sebastian Maurer-Stroh, Paul Anantharajah Tambyah
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引用次数: 0

Abstract

Abstract: All pandemic viruses have eventually adapted to human hosts so that they become more transmissible and less virulent. The XBB Omicron subvariant is rapidly becoming the dominant strain of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Singapore from October 2022 and is one of several variants circulating globally with the potential to dominate autumn/winter waves in different countries. The XBB Omicron subvariant has demonstrated increased transmissibility through an apparent propensity for immune evasion. This is to be expected in the natural evolution of a virus in a population highly vaccinated with a vaccine targeting the spike protein of the original Wuhan strain of the virus. This review explores the important implications of the rising prevalence of the SARS-CoV-2 Omicron subvariant for public health in Singapore and beyond.

COVID-19 XBB Omicron 子变体是否预示着大流行开始结束?
所有大流行病毒最终都会适应人类宿主,从而变得更易传播、毒性更弱。从 2022 年 10 月起,XBB Omicron 亚变种正迅速成为新加坡严重急性呼吸系统综合症冠状病毒-2(SARS-CoV-2)的优势毒株,也是全球流行的几个变种之一,有可能在不同国家的秋冬季流行中占主导地位。XBB Omicron 亚变异体因具有明显的免疫逃避倾向而显示出更强的传播性。在接种了针对武汉病毒原始毒株尖峰蛋白疫苗的高度接种人群中,病毒的自然进化过程中出现这种情况是意料之中的。本综述探讨了 SARS-CoV-2 Omicron 亚变异株流行率上升对新加坡及其他地区公共卫生的重要影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Singapore medical journal
Singapore medical journal MEDICINE, GENERAL & INTERNAL-
CiteScore
3.40
自引率
3.70%
发文量
149
审稿时长
3-6 weeks
期刊介绍: The Singapore Medical Journal (SMJ) is the monthly publication of Singapore Medical Association (SMA). The Journal aims to advance medical practice and clinical research by publishing high-quality articles that add to the clinical knowledge of physicians in Singapore and worldwide. SMJ is a general medical journal that focuses on all aspects of human health. The Journal publishes commissioned reviews, commentaries and editorials, original research, a small number of outstanding case reports, continuing medical education articles (ECG Series, Clinics in Diagnostic Imaging, Pictorial Essays, Practice Integration & Life-long Learning [PILL] Series), and short communications in the form of letters to the editor.
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