Recent Updates on Associations among Various Obesity Metrics and Cognitive Impairment: from Body Mass Index to Sarcopenic Obesity.

IF 4.7 Q1 ENDOCRINOLOGY & METABOLISM
Chan-Hee Jung, Ji-Oh Mok
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引用次数: 0

Abstract

Obesity and obesity-associated morbidity continues to be a major public health issue worldwide. Dementia is also a major health concern in aging societies and its prevalence has increased rapidly. Many epidemiologic studies have shown an association between obesity and cognitive impairment, but this relationship is not as well established as other comorbidities. Conflicting results related to the age and sex of participants, and the methodology used to define obesity and dementia may account for the uncertainty in whether obesity is a modifiable risk factor for dementia. More recently, sarcopenia and sarcopenic obesity have been reported to be associated with cognitive impairment. In addition, new mediators such as the muscle-myokine-brain axis and gut-microbiota-brain axis have been suggested and are attracting interest. In this review, we summarize recent evidence on the link between obesity and cognitive impairment, especially dementia. In particular, we focus on various metrics of obesity, from body mass index to sarcopenia and sarcopenic obesity.

Abstract Image

Abstract Image

各种肥胖指标与认知障碍之间关系的最新进展:从体重指数到肌少性肥胖。
肥胖和与肥胖相关的发病率仍然是世界范围内的一个主要公共卫生问题。痴呆症也是老龄化社会的一个主要健康问题,其患病率迅速上升。许多流行病学研究表明肥胖和认知障碍之间存在关联,但这种关系并不像其他合并症那样得到很好的证实。与参与者的年龄和性别有关的相互矛盾的结果,以及用于定义肥胖和痴呆的方法,可能解释了肥胖是否是痴呆的可改变风险因素的不确定性。最近,有报道称肌肉减少症和肌肉减少性肥胖与认知障碍有关。此外,新的介质如肌肉-肌因子-脑轴和肠道-微生物群-脑轴也被提出并引起了人们的兴趣。在这篇综述中,我们总结了最近关于肥胖和认知障碍,特别是痴呆之间联系的证据。我们特别关注肥胖的各种指标,从体重指数到肌肉减少症和肌肉减少性肥胖。
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来源期刊
Journal of Obesity & Metabolic Syndrome
Journal of Obesity & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-
CiteScore
8.30
自引率
9.60%
发文量
39
审稿时长
19 weeks
期刊介绍: The journal was launched in 1992 and diverse studies on obesity have been published under the title of Journal of Korean Society for the Study of Obesity until 2004. Since 2017, volume 26, the title is now the Journal of Obesity & Metabolic Syndrome (pISSN 2508-6235, eISSN 2508-7576). The journal is published quarterly on March 30th, June 30th, September 30th and December 30th. The official title of the journal is now "Journal of Obesity & Metabolic Syndrome" and the abbreviated title is "J Obes Metab Syndr". Index words from medical subject headings (MeSH) list of Index Medicus are included in each article to facilitate article search. Some or all of the articles of this journal are included in the index of PubMed, PubMed Central, Scopus, Embase, DOAJ, Ebsco, KCI, KoreaMed, KoMCI, Science Central, Crossref Metadata Search, Google Scholar, and Emerging Sources Citation Index (ESCI).
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