Utility of extracellular matrix powders in tissue engineering.

IF 1.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Organogenesis Pub Date : 2018-01-01 DOI:10.1080/15476278.2018.1503771

Lauren Edgar, Afnan Altamimi, Marta García Sánchez, Riccardo Tamburrinia, Amish Asthana, Carlo Gazia, Giuseppe Orlando

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引用次数: 26

Abstract

Extracellular matrix (ECM) materials have had remarkable success as scaffolds in tissue engineering (TE) and as therapies for tissue injury whereby the ECM microenvironment promotes constructive remodeling and tissue regeneration. ECM powder and solubilized derivatives thereof have novel applications in TE and RM afforded by the capacity of these constructs to be dynamically modulated. The powder form allows for effective incorporation and penetration of reagents; hence, ECM powder is an efficacious platform for 3D cell culture and vehicle for small molecule delivery. ECM powder offers minimally invasive therapy for tissue injury and successfully treatment for wounds refractory to first-line therapies. Comminution of ECM and fabrication of powder-derived constructs, however, may compromise the biological integrity of the ECM. The current lack of optimized fabrication protocols prevents a more extensive and effective clinical application of ECM powders. Further study on methods of ECM powder fabrication and modification is needed.

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细胞外基质粉末在组织工程中的应用。

细胞外基质(ECM)材料作为组织工程(TE)的支架和组织损伤的治疗已经取得了显著的成功，其中ECM微环境促进了建设性的重塑和组织再生。ECM粉末及其溶解衍生物在TE和RM中具有新的应用，因为这些结构具有动态调制的能力。粉末形式允许试剂的有效掺入和渗透;因此，ECM粉末是一种有效的3D细胞培养平台和小分子递送载体。ECM粉末为组织损伤提供了微创治疗，并成功治疗了难以一线治疗的伤口。然而，ECM的粉碎和粉末衍生结构的制造可能会损害ECM的生物完整性。目前缺乏优化的制造方案，阻碍了ECM粉末更广泛和有效的临床应用。电解加工粉末的制备和改性方法有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY

CiteScore

4.10

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.