Mechanisms of acupuncture-electroacupuncture on inflammatory pain.

IF 2.8 3区 医学 Q2 NEUROSCIENCES
Qingxiang Zhang, Mengmeng Zhou, Mingzhu Huo, Yuxin Si, Youlin Zhang, Yuxin Fang, Di Zhang
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引用次数: 0

Abstract

Acupuncture, as a traditional treatment, has been extensively used in China for thousands of years. According to the World Health Organization (WHO), acupuncture is recommended for the treatment of 77 diseases. And 16 of these diseases are related to inflammatory pain. As a combination of traditional acupuncture and modern electrotherapy, electroacupuncture (EA) has satisfactory analgesic effects on various acute and chronic pain. Because of its good analgesic effects and no side effects, acupuncture has been widely accepted all over the world. Despite the increase in the number of studies, the mechanisms via which acupuncture exerts its analgesic effects have not been conclusively established. A literature review of related research is of great significance to elaborate on its mechanisms and to inform on further research directions. We elucidated on its mechanisms of action on inflammatory pain from two levels: peripheral and central. It includes the mechanisms of acupuncture in the periphery (immune cells and neurons, purinergic pathway, nociceptive ion channel, cannabinoid receptor and endogenous opioid peptide system) and central nervous system (TPRV1, glutamate and its receptors, glial cells, GABAergic interneurons and signaling molecules). In this review, we collected relevant recent studies to systematically explain the mechanisms of acupuncture in treating inflammatory pain, with a view to providing direction for future applications of acupuncture in inflammatory pain and promoting clinical development.

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针刺电针治疗炎症性疼痛的机制。
针灸作为一种传统疗法,在中国已经广泛应用了数千年。根据世界卫生组织(世界卫生组织),针灸被推荐用于治疗77种疾病。其中16种疾病与炎症性疼痛有关。电针作为传统针灸与现代电疗的结合,对各种急慢性疼痛具有满意的镇痛效果。针灸因其镇痛效果好、无副作用,已被世界各国广泛接受。尽管研究数量有所增加,但针灸发挥镇痛作用的机制尚未最终确定。对相关研究的文献综述对于阐明其机制和为进一步的研究方向提供信息具有重要意义。我们从外周和中枢两个层面阐明了其对炎症性疼痛的作用机制。它包括针刺在外周(免疫细胞和神经元、嘌呤能通路、伤害性离子通道、大麻素受体和内源性阿片肽系统)和中枢神经系统(TPRV1、谷氨酸及其受体、神经胶质细胞、GABA能中间神经元和信号分子)中的机制。在这篇综述中,我们收集了最近的相关研究,系统地解释了针灸治疗炎症性疼痛的机制,以期为针灸在炎症性疼痛中的未来应用提供方向,促进临床发展。
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来源期刊
Molecular Pain
Molecular Pain 医学-神经科学
CiteScore
5.60
自引率
3.00%
发文量
56
审稿时长
6-12 weeks
期刊介绍: Molecular Pain is a peer-reviewed, open access journal that considers manuscripts in pain research at the cellular, subcellular and molecular levels. Molecular Pain provides a forum for molecular pain scientists to communicate their research findings in a targeted manner to others in this important and growing field.
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