Association between soft drink consumption types and risk of lung cancer and all-cancer: A prospective study of PLCO data.

IF 2.2 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Dongfang You, Hongyang Xu, Xin Chen, Jiawei Zhou, Yaqian Wu, Yingdan Tang, Zhongtian Wang, Yang Zhao, Fang Shao
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Abstract

Diet/sugar-free soft drinks are considered to be healthier than regular soft drinks. However, few studies have examined the relationship between the types of soft drinks (regular and diet/sugar-free) and lung cancer (LC)/all-cancer (AC) risk. In this study, we comprehensively assessed the influence of the type of soft drink consumption on LC/AC risk based on the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Multivariable Cox proportional hazards and competing risks Fine-Gray regression models adjusted for relevant confounders were used to estimate hazard ratios (HRs) and subdistribution HRs for different types of soft drink consumption. In the PLCO population, female subgroup, and the ever/current smoker subgroup, consumption of both regular and diet soft drinks was associated with a significantly reduced risk of LC compared with no soft drinks at all. For the non-lung cancer (NLC) risk, consumption of only diet soft drinks had a significant positive association for the total population and female subgroup. Based on our findings, it was suggested that partial replacement of regular soft drinks with diet soft drinks might be beneficial to LC prevention, especially for females and ever/current smokers. Additionally, completely replacing regular soft drinks with diet soft drinks might be detrimental to NLC prevention, especially for females.

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软饮料消费类型与肺癌和所有癌症风险之间的关系:PLCO数据的前瞻性研究。
无糖软饮料被认为比普通软饮料更健康。然而,很少有研究调查软饮料类型(普通饮料和无糖饮料)与肺癌(LC)/所有癌症(AC)风险之间的关系。在本研究中,我们基于前列腺、肺、结直肠和卵巢(PLCO)癌症筛查试验,综合评估了软饮料消费类型对LC/AC风险的影响。多变量Cox比例风险和竞争风险采用调整相关混杂因素的细灰色回归模型来估计不同类型软饮料消费的风险比(hr)和亚分布hr。在PLCO人群、女性亚组和曾经/现在吸烟者亚组中,与完全不喝软饮料相比,饮用常规软饮料和无糖软饮料与LC风险显著降低相关。对于非肺癌(NLC)风险,仅饮用无糖软饮料对总人口和女性亚组有显著的正相关。根据我们的研究结果,建议用无糖软饮料部分替代常规软饮料可能有利于预防LC,特别是对于女性和曾经/现在的吸烟者。此外,用无糖软饮料完全取代普通软饮料可能不利于NLC的预防,尤其是对女性。
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来源期刊
Journal of Biomedical Research
Journal of Biomedical Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
4.60
自引率
0.00%
发文量
69
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