Natural Polymers as a Carrier for the Effective Delivery of Antineoplastic Drugs.

IF 3.1 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug delivery Pub Date : 2024-01-01 DOI:10.2174/1567201820666230112170035

Rajat Patel, Utkarsha Kuwar, Nidhi Dhote, Amit Alexander, Kartik Nakhate, Parag Jain, Ajazuddin

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引用次数: 0

Abstract

Cancer is a broad term for a set of disorders marked by the development of physically and functionally changed cells that proliferate uncontrollably, infect neighboring tissues, and result in malignant tumours, 'neoplasm'. Cancer remains a difficult disease to treat because of the significant adverse effects and poor pharmacokinetic profile of antineoplastic drugs, despite advancements in our understanding of the features and behavior of tumor cells in recent decades. In this series, the role of natural polymers is prominent as a component of a novel delivery system of anticancer drugs. These natural polymeric drug delivery systems (NPDDS) have many advantages over synthetic polymers like controlled delivery, biodegradability, inexpensive, low toxicity profile, and easily obtainable. These polymers further modify for the targeting of tumour cells. This review discusses and critically analyses the different natural polymers, such as chitosan, cellulose, starch, albumin, dextran, fucoidan, gelatin, etc., in terms of natural ingredient-based polymeric nanocarriers specifically for cancer therapy. It also describes benefits, drawbacks, and opinions and provides insights about the efficacy of NPDDS as well as its future perspectives and tabulated recent patents and cases under clinical trials exploited for cancer treatment.

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天然聚合物作为抗肿瘤药物有效递送的载体。

癌症是一系列疾病的广义术语，其特征是发生物理和功能改变的细胞，这些细胞不受控制地增殖，感染邻近组织，并导致恶性肿瘤，即“肿瘤”。尽管近几十年来我们对肿瘤细胞的特征和行为的理解有所进步，但癌症仍然是一种难以治疗的疾病，因为抗肿瘤药物具有显著的不良反应和不良的药代动力学特征。在该系列中，天然聚合物作为新型抗癌药物递送系统的组成部分发挥着重要作用。与合成聚合物相比，这些天然聚合物药物递送系统（NPDDS）具有许多优点，如可控递送、生物降解性、廉价、低毒性和易于获得。这些聚合物进一步修饰以靶向肿瘤细胞。本文对壳聚糖、纤维素、淀粉、白蛋白、右旋糖酐、褐藻糖胶、明胶等天然高分子材料作为癌症治疗专用的天然纳米载体进行了综述和分析。它还描述了益处、缺点和观点，并提供了关于NPDDS疗效及其未来前景的见解，并列出了用于癌症治疗的临床试验中的最新专利和病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.10

自引率

4.20%

发文量

170

期刊介绍： Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.