Vascular stiffness and healthy arterial aging in older patients with optimal blood pressure.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-07-01 DOI:10.1590/2175-8239-JBN-2022-0123en

Alessandra Ferreira Mendes Jiticovski, Denis Fabiano Souza, Ercilhana Gonçalves Batista Freitas, Cléria Rodrigues Ferreira, Cristiane de Sousa Pereira, Romário Divino Vilarinho Galvão, Walkiria de Almeida Martins Santos, Erick P de Oliveira, Sebastião Rodrigues Ferreira Filho

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引用次数: 1

Abstract

Introduction: Pulse wave velocity is used to diagnose central arterial stiffness (CAS) and quantify healthy vascular aging (HVA).

Objective: To evaluate the CAS and HVA in elderly patients with systemic blood pressure levels classified as optimal/normal.

Methods: A total of 102 patients without comorbidities and with systolic pressure (SP) < 120 mmHg and diastolic pressure (DP) < 80 mmHg were selected from the EVOPIU database (Pulse Wave Velocity of Elderly Individuals in an Urban area of Brazil). The carotid-femoral pulse wave velocity (c-fPWV) and the central and peripheral pressures were evaluated in all patients. The patients were divided into four groups: G1: (n = 19, with c-fPWV < 7.6 m/s, without medication), G2 (n = 26, c-fPWV ≥ 7.6 m/s; without medication), G3 (n = 25, c-fPWV < 7.6 m/s with antihypertensive medication), and G4 (n = 32, c-fPWV ≥ 7.6 m/s with antihypertensive medication).

Results: In our sample, 56.7% of patients had c-fPWV ≥ 7.6 m/s. The central systolic pressure in G1 [99 (10) mmHg] was lower than that found in the other three groups [vs. 112 (14) mmHg, 111 (15), 112 (20) mmHg; P < 0.05)].

Conclusion: Older people with optimal arterial blood pressure do not necessarily have HVA and could have c-fPWV values close to the limits established for CAS diagnosis.

查看原文本刊更多论文

老年最佳血压患者血管僵硬与健康动脉老化。

脉搏波速度用于诊断中央动脉硬度(CAS)和量化健康血管老化(HVA)。目的:评价老年体血压水平为最佳/正常的患者的CAS和HVA。方法:选取巴西城市地区EVOPIU数据库中收缩压(SP) < 120 mmHg、舒张压(DP) < 80 mmHg、无合并症的102例患者。评估所有患者的颈股动脉脉波速度(c-fPWV)和中央和外周压力。患者分为4组:G1组(n = 19, c-fPWV < 7.6 m/s，未用药)，G2组(n = 26, c-fPWV≥7.6 m/s;G3组(n = 25，服用降压药后c-fPWV < 7.6 m/s)， G4组(n = 32，服用降压药后c-fPWV≥7.6 m/s)。结果:在我们的样本中，56.7%的患者c-fPWV≥7.6 m/s。G1组中央收缩压[99 (10)mmHg]低于其他三组[vs. 112 (14) mmHg, 111 (15)， 112 (20) mmHg;P < 0.05)。结论:动脉血压最佳的老年人不一定患有HVA，其c-fPWV值可能接近CAS诊断的限值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.