SATB2 Cytoplasmic Expression is Characteristic of a Subset of Ovarian Stromal Cells and Sex Cord Stromal Tumors.

IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
Maysa Al-Hussaini, W Glenn McCluggage
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引用次数: 0

Abstract

Special AT-rich sequence-binding protein 2 (SATB2) is a nuclear transcription factor that shows consistent nuclear staining in colorectal adenocarcinoma and osteosarcoma. Following the observation of cytoplasmic staining with this marker in luteinized ovarian stromal cells, we studied the expression of SATB2 in ovarian stromal cells, various types of follicular cysts, and sex cord-stromal tumors. Eighty-five cases were stained for SATB2. Ovarian hilar Leydig cells (n = 12), luteinized stromal cells (n = 10), corpora lutea (n = 4), luteinized follicular cysts (n = 4), and stromal hyperthecosis (n = 6) exhibited consistent, usually diffuse, granular cytoplasmic staining. In addition, Leydig cell tumors (n = 1) and steroid cell tumors (n = 4) showed diffuse cytoplasmic staining. SATB2 also exhibited cytoplasmic staining in most Sertoli-Leydig cell tumors (n = 16) and gynandroblastomas (n = 3) confined to the Leydig cell component. Adult granulosa cell tumors (n = 14), juvenile granulosa cell tumors (n = 3), sex cord tumors with annular tubules (n = 3), cellular fibromas (n = 3), sclerosing stromal tumors (n = 1), and thecomas (n = 1) were negative apart from cytoplasmic staining in associated luteinized stromal cells. SATB2 cytoplasmic staining has not been previously described in these lesions but is characteristic of a variety of ovarian stromal cells and sex cord-stromal tumors, in particular, those exhibiting luteinization or a Leydig or steroid cell component. SATB2 staining may be of value in identifying luteinized or Leydig cells when these are morphologically inconspicuous.

SATB2 细胞质表达是卵巢间质细胞和性索间质瘤亚群的特征。
特殊富AT序列结合蛋白2(SATB2)是一种核转录因子,在结直肠腺癌和骨肉瘤中显示出一致的核染色。继在黄体化卵巢基质细胞中观察到该标记物的细胞质染色后,我们研究了 SATB2 在卵巢基质细胞、各种类型的卵泡囊肿和性索间质肿瘤中的表达。85 个病例进行了 SATB2 染色。卵巢间质Leydig细胞(12例)、黄体化间质细胞(10例)、黄体(4例)、黄体化卵泡囊肿(4例)和间质肥大症(6例)表现出一致的、通常是弥漫性的颗粒状胞浆染色。此外,Leydig 细胞肿瘤(n = 1)和类固醇细胞肿瘤(n = 4)也表现出弥漫性胞浆染色。SATB2 在大多数 Sertoli-Leydig 细胞肿瘤(n = 16)和妇母细胞瘤(n = 3)中也表现出胞浆染色,但仅限于 Leydig 细胞部分。成人颗粒细胞瘤(14 例)、幼年颗粒细胞瘤(3 例)、环状小管性索瘤(3 例)、细胞纤维瘤(3 例)、硬化性基质瘤(1 例)和肉瘤(1 例)除相关黄体化基质细胞出现细胞质染色外,其他均为阴性。SATB2 细胞质染色以前未在这些病变中出现过,但它是各种卵巢基质细胞和性索间质肿瘤的特征,尤其是那些黄体化或具有莱地格或类固醇细胞成分的肿瘤。当黄体化或Leydig细胞在形态上不明显时,SATB2染色可能有助于鉴别这些细胞。
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来源期刊
CiteScore
3.90
自引率
12.50%
发文量
154
审稿时长
6-12 weeks
期刊介绍: International Journal of Gynecological Pathology is the official journal of the International Society of Gynecological Pathologists (ISGyP), and provides complete and timely coverage of advances in the understanding and management of gynecological disease. Emphasis is placed on investigations in the field of anatomic pathology. Articles devoted to experimental or animal pathology clearly relevant to an understanding of human disease are published, as are pathological and clinicopathological studies and individual case reports that offer new insights.
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