Diagnostic accuracy of copeptin and NT-proBNP level in predicting mortality and postoperative prognosis in coronary surgery with respect to EuroSCORE risk.

IF 0.6 Q4 SURGERY
Sinan Göçer, Ekin Ilkeli, Ali Cemal Düzgün
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引用次数: 1

Abstract

Introduction: During the last few years, many modifications in risk stratification of all cardiac surgical patients have been reported based on EuroSCORE.

Aim: In this study we aimed to interpret copeptin and NT-proBNP levels in patients who had undergone coronary surgery with respect to EuroSCORE.

Material and methods: We investigated the correlation between pre-operative copeptin and NT-proBNP levels with respect to mortality and post-operative complications via EuroSCORE II in the 484 enrolled patients. In terms of analyzing mortality the first 30 days were taken into account and duration of hospital stay was considered for prognosis. The statistical significance of copeptin and NT-proBNP with respect to EuroSCORE II ≥ 2 was studied.

Results: The critical threshold levels of mortality for NT-proBNP was 1296 pg/ml and for copeptin was 116 pmol/l in patients whose EuroSCORE II ≥ 2. Mortality increases 9.04-fold in cases with EuroSCORE ≥ 2, 5.04-fold when NT-proBNP level is > 1296 pg/ml. A dramatic outcome was observed in copeptin levels as mortality increased 138.17-fold when copeptin was > 116 pmol/l.

Conclusions: Increased levels of copeptin and NT-proBNP negatively affect mortality and complication rates in isolated cardiac surgery patients.

Abstract Image

copeptin和NT-proBNP水平预测冠状动脉手术死亡率和术后预后的准确性与EuroSCORE风险的关系
在过去的几年中,根据EuroSCORE报告了所有心脏手术患者风险分层的许多修改。目的:在这项研究中,我们旨在解释接受冠状动脉手术患者的copeptin和NT-proBNP水平与EuroSCORE的关系。材料和方法:我们通过EuroSCORE II研究了484例入组患者术前copeptin和NT-proBNP水平与死亡率和术后并发症的相关性。在分析死亡率方面,考虑了前30天的死亡率,并考虑了住院时间作为预后因素。研究copeptin和NT-proBNP对EuroSCORE II≥2的统计学意义。结果:在EuroSCORE II≥2的患者中,NT-proBNP的死亡率临界值水平为1296 pg/ml, copeptin的死亡率临界值水平为116 pmol/l。EuroSCORE≥2时死亡率增加9.04倍,NT-proBNP > 1296 pg/ml时死亡率增加5.04倍。当copeptin > 116 pmol/l时,死亡率增加138.17倍。结论:copeptin和NT-proBNP水平升高对孤立心脏手术患者的死亡率和并发症发生率有负面影响。
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来源期刊
CiteScore
0.90
自引率
14.30%
发文量
44
审稿时长
6-12 weeks
期刊介绍: Polish Journal of Thoracic and Cardiovascular Surgery is a quarterly aimed at cardiologists, cardiosurgeons and thoracic surgeons. Includes the original works (experimental, research and development), illustrative and casuistical works about cardiology and cardiosurgery.
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