Estimation of a cut-off value for immature platelet fraction (IPF) in predicting platelet recovery in dengue patients with thrombocytopenia.

IF 0.6 4区医学 Q4 PATHOLOGY

Malaysian Journal of Pathology Pub Date : 2022-12-01

J Ahmad, S Md Noor, S Z Mustapha, F Idris

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引用次数: 0

Abstract

Introduction: Thrombocytopenia is a common complication in dengue that sometimes necessitates platelet transfusion. Immature platelet fraction (IPF) measures immature platelets that indirectly reflect thrombopoiesis and is helpful in predicting platelet recovery.

Objectives: This study aimed to evaluate the role of IPF% and identify its cut-off value in predicting platelet recovery in dengue patients with thrombocytopenia.

Materials and methods: Serial platelet count and IPF results were obtained from fifty-four confirmed dengue patients with platelet count <50x109 /L. Median peak IPF% and number of patients with platelet recovery were determined. Receiver operating characteristic (ROC) curve is generated to identify the IPF% cut-off value to predict platelet recovery.

Results: Median peak IPF% among dengue patients was 12.15% with 83.3% of them achieving platelet recovery after reaching the peak IPF%. There was a significant difference between median IPF% on day one of admission with peak IPF% among dengue patients. ROC curve analysis showed IFP% of 10.55% can be used to predict platelet recovery with a sensitivity of 69% and a specificity of 67%.

Conclusion: IPF% is a reliable and useful parameter in predicting platelet recovery in dengue patients. This would assist the clinician in managing dengue patients especially those with severe thrombocytopenia without giving unnecessary platelet transfusion.

本刊更多论文

未成熟血小板分数(IPF)在预测登革热伴血小板减少患者血小板恢复中的临界值估计。

血小板减少症是登革热的常见并发症，有时需要输血小板。未成熟血小板分数(IPF)测量未成熟血小板，间接反映血小板生成，有助于预测血小板恢复。目的:本研究旨在评估IPF%在预测登革热伴血小板减少患者血小板恢复中的作用，并确定其临界值。材料与方法:对54例有血小板计数的登革热确诊患者进行血小板计数和IPF序列分析。结果:登革热患者IPF%峰值中位数为12.15%，达到IPF%峰值后血小板恢复率为83.3%。登革热患者入院第一天的中位IPF%与峰值IPF%之间存在显著差异。ROC曲线分析显示，IFP值为10.55%，预测血小板恢复的灵敏度为69%，特异性为67%。结论:IPF%是预测登革热患者血小板恢复的可靠指标。这将有助于临床医生管理登革热患者，特别是那些严重的血小板减少症患者，而无需给予不必要的血小板输注。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Malaysian Journal of Pathology PATHOLOGY-

CiteScore

3.60

自引率

5.60%

发文量

期刊介绍： The Malaysian Journal of Pathology is the official journal of the College of Pathologists, Academy of Medicine Malaysia. The primary purpose of The Journal is to publish the results of study and research in Pathology, especially those that have particular relevance to human disease occurring in Malaysia and other countries in this region. The term PATHOLOGY will be interpreted in its broadest sense to include Chemical Pathology, Cytology, Experimental Pathology, Forensic Pathology, Haematology, Histopathology, Immunology, Medical Microbiology and Parasitology. The Journal aims to bring under one cover publications of regional interest embracing the various sub-specialities of Pathology. It is expected that the articles published would be of value not only to pathologists, but also to medical practitioners in search of a scientific basis for the problems encountered in their practice, and to those with an interest in diseases which occur in the tropics.