Bee venom ameliorates oxidative stress and histopathological changes of hippocampus, liver and testis during status epileptics

IF 2.5 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Neuropeptides Pub Date : 2023-10-01 DOI:10.1016/j.npep.2023.102368

Esraa K. Aly , Hanan S. Mahmoud , Dalal Hussien M. Alkhalifah , Gaber M.G. Shehab , Abdelaziz S.A. Abuelsaad , Eman S. Abdel-Rehiem , Manal Abdul-Hamid

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引用次数: 0

Abstract

The unrelenting progression of neurodegenerative diseases has a negative impact on affected individuals, their families, and society. Recurrent epileptic seizures are the hallmark of epilepsy, and treating it effectively remains difficult. Clarify and understanding effects of the antiepileptic drugs (AEDs) in epilepsy by comparing the therapeutic effects between rats receiving valproic acid (VPA) and Bee venom (BV) was aimed throughout the present study. Four male Wistar rat groups were included: control, epileptic group receiving pilocarpine (PILO), epileptic group treated with VPA and BV respectively. Cognitive functions were assessed by evaluating latency time in hot plate, despair swim test, grooming, rearing and ambulation frequency in the open field. BV has ameliorative effect on electrolytes balancing, assured by decreasing lipid peroxidation, nitric oxide and increasing catalase, superoxide dismutase and glutathione peroxidase activities. BV enhanced restoration of liver functions indicated by alanine transaminase (ALT) and aspartate transaminase (AST), total proteins, and albumin; hormonal parameters total and free testosterone, follicle stimulating hormone (FSH) and Luteinizing hormone (LH) were preserved by BV with great recovery of hippocampus, liver and testicular histopathology and ultrastructure comparing with the epileptic rats. The present findings suggested that BV and its active components offer fresh options for controlling epilepsy and prospective methods via minimize or manage the severe consequences.

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蜂毒可改善癫痫状态时海马、肝脏和睾丸的氧化应激和组织病理学改变

神经退行性疾病的不断发展对受影响的个人、家庭和社会产生了负面影响。复发性癫痫发作是癫痫的标志，有效治疗仍然很困难。本研究旨在通过比较丙戊酸(VPA)和蜂毒(BV)对癫痫大鼠的治疗效果，阐明和了解抗癫痫药物(aed)对癫痫的作用。雄性Wistar大鼠分为4组:对照组、癫痫组(匹罗卡平)、癫痫组(VPA)和BV组。通过热板测试潜伏期、绝望游泳测试、梳理、饲养和野外行走频率评估认知功能。BV通过降低脂质过氧化、一氧化氮和增加过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶活性来改善电解质平衡。BV促进肝功能恢复，以谷丙转氨酶(ALT)和天冬氨酸转氨酶(AST)、总蛋白和白蛋白为指标;激素参数:总睾酮、游离睾酮、促卵泡激素(FSH)、促黄体生成素(LH)保存完好，海马、肝脏、睾丸组织病理及超微结构较癫痫大鼠恢复明显。目前的研究结果表明，BV及其活性成分为控制癫痫提供了新的选择，并通过减少或控制严重后果提供了前瞻性的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropeptides 医学-内分泌学与代谢

CiteScore

5.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.