Genetic risk scores associated with temperament clusters in Finnish depression patients.

IF 3.8 4区医学 Q1 Medicine

Acta Neuropsychiatrica Pub Date : 2024-02-01 Epub Date: 2023-09-04 DOI:10.1017/neu.2023.33

Simo-Pekko Salminen, Anssi Solismaa, Leo-Pekka Lyytikäinen, Vesa Paavonen, Nina Mononen, Terho Lehtimäki, Esa Leinonen, Olli Kampman

{"title":"Genetic risk scores associated with temperament clusters in Finnish depression patients.","authors":"Simo-Pekko Salminen, Anssi Solismaa, Leo-Pekka Lyytikäinen, Vesa Paavonen, Nina Mononen, Terho Lehtimäki, Esa Leinonen, Olli Kampman","doi":"10.1017/neu.2023.33","DOIUrl":null,"url":null,"abstract":"Objective: Cloninger's temperament dimensions have been studied widely in relation to genetics. In this study, we examined Cloninger's temperament dimensions grouped with cluster analyses and their association with single nucleotide polymorphisms (SNPs). This study included 212 genotyped Finnish patients from the Ostrobothnia Depression Study.Methods: The temperament clusters were analysed at baseline and at six weeks from the beginning of the depression intervention study. We selected depression-related catecholamine and serotonin genes based on a literature search, and 59 SNPs from ten different genes were analysed. The associations of single SNPs with temperament clusters were studied. Using the selected genes, genetic risk score (GRS) analyses were conducted considering appropriate confounding factors.Results: No single SNP had a significant association with the temperament clusters. Associations between GRSs and temperament clusters were observed in multivariate models that were significant after permutation analyses. Two SNPs from the DRD3 gene, two SNPs from the SLC6A2 gene, one SNP from the SLC6A4 gene, and one SNP from the HTR2A gene associated with the HHA/LRD/LP (high harm avoidance, low reward dependence, low persistence) cluster at baseline. Two SNPs from the HTR2A gene were associated with the HHA/LRD/LP cluster at six weeks. Two SNPs from the HTR2A gene and two SNPs from the COMT gene were associated with the HP (high persistence) cluster at six weeks.Conclusion: GRSs seem to associate with an individual's temperament profile, which can be observed in the clusters used. Further research needs to be conducted on these types of clusters and their clinical applicability.","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"51-59"},"PeriodicalIF":3.8000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Neuropsychiatrica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/neu.2023.33","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/4 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Cloninger's temperament dimensions have been studied widely in relation to genetics. In this study, we examined Cloninger's temperament dimensions grouped with cluster analyses and their association with single nucleotide polymorphisms (SNPs). This study included 212 genotyped Finnish patients from the Ostrobothnia Depression Study.

Methods: The temperament clusters were analysed at baseline and at six weeks from the beginning of the depression intervention study. We selected depression-related catecholamine and serotonin genes based on a literature search, and 59 SNPs from ten different genes were analysed. The associations of single SNPs with temperament clusters were studied. Using the selected genes, genetic risk score (GRS) analyses were conducted considering appropriate confounding factors.

Results: No single SNP had a significant association with the temperament clusters. Associations between GRSs and temperament clusters were observed in multivariate models that were significant after permutation analyses. Two SNPs from the DRD3 gene, two SNPs from the SLC6A2 gene, one SNP from the SLC6A4 gene, and one SNP from the HTR2A gene associated with the HHA/LRD/LP (high harm avoidance, low reward dependence, low persistence) cluster at baseline. Two SNPs from the HTR2A gene were associated with the HHA/LRD/LP cluster at six weeks. Two SNPs from the HTR2A gene and two SNPs from the COMT gene were associated with the HP (high persistence) cluster at six weeks.

Conclusion: GRSs seem to associate with an individual's temperament profile, which can be observed in the clusters used. Further research needs to be conducted on these types of clusters and their clinical applicability.

查看原文本刊更多论文

芬兰抑郁症患者的遗传风险评分与气质聚类相关。

目的：Cloninger的气质维度已被广泛研究与遗传学有关。在这项研究中，我们通过聚类分析检验了Cloninger的气质维度及其与单核苷酸多态性（SNPs）的关系。这项研究包括212名来自鸵鸟抑郁症研究的基因型芬兰患者。方法：在基线和抑郁症干预研究开始后6周对气质聚类进行分析。我们在文献检索的基础上选择了与抑郁症相关的儿茶酚胺和血清素基因，并分析了来自10个不同基因的59个SNPs。研究了单个SNPs与气质簇的关系。使用选定的基因，进行遗传风险评分（GRS）分析，考虑适当的混杂因素。结果：没有一个SNP与气质聚类有显著的相关性。在排列分析后显著的多变量模型中观察到GRS和气质聚类之间的关联。两个来自DRD3基因的SNP，两个来自SLC6A2基因的SNPs，一个来自SLC6A4基因的SNPs，以及一个来自HTR2A基因的与基线时的HHA/LRD/LP（高伤害避免、低回报依赖、低持久性）簇相关的SNP。来自HTR2A基因的两个SNPs在6周时与HHA/LRD/LP簇相关。来自HTR2A基因的两个SNPs和来自COMT基因的两种SNPs在六周时与HP（高持久性）簇相关。结论：GRS似乎与个人的气质特征有关，这可以在所使用的聚类中观察到。需要对这些类型的集群及其临床适用性进行进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Acta Neuropsychiatrica 医学-精神病学

CiteScore

8.50

自引率

5.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.