Low Intake of Choline Is Associated with Diminished Strength and Lean Mass Gains in Older Adults.

IF 3.3 Q2 GERIATRICS & GERONTOLOGY

Journal of Frailty & Aging Pub Date : 2023-01-01 DOI:10.14283/jfa.2022.50

C W Lee, E Galvan, T V Lee, V C W Chen, S Bui, S F Crouse, J D Fluckey, S B Smith, S E Riechman

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引用次数: 1

Abstract

Objectives: Choline is an essential micronutrient for many physiological processes related to exercise training including biosynthesis of acetylcholine. Though dietary choline intake has been studied in relation to endurance training and performance, none have studied it during resistance exercise training (RET) in older adults. The objective of the study was to examine the relationship between choline intake and muscle responses to RET in older adults.

Methods: Forty-six, 60-69-year-old individuals (M=19, F=27) underwent 12 weeks of RET (3x/week, 3 sets, 8-12 reps, 75% of maximum strength [1RM], 8 exercises). Body composition (DEXA) and 1RM tests were performed before and after training. After analyzing 1,656 diet logs (3x/week, 46 participants, 12 weeks), participants' mean choline intakes were categorized into three groups: Low (2.9-5.5 mg/kg lean/d), Med-Low (5.6-8.0 mg/kg lean/d), or Adequate (8.1-10.6 mg/kg lean/d). These correspond to <50%, ~63%, and ~85% of Adequate Intake (AI) for choline, respectively.

Results: Gains in composite strength (leg press + chest press 1RM) were significantly lower in the Low group compared with the other groups (Low: 30.9 ± 15.1%, Med-Low: 70.3 ± 48.5%, Adequate: 81.9 ± 68.4%; p=0.004). ANCOVA with cholesterol, protein, or other nutrients did not alter this result. Reduced gains in lean mass were also observed in the Low group, compared with higher choline intake of 5.6-10.6 mg/kg lean/d (1.3 ± 0.6% vs. 3.2 ± 0.6%, p<0.05).

Conclusion: These data suggest that this population of older adults does not consume adequate choline and lower choline intake is negatively and independently associated with muscle responses to RET.

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低胆碱摄入量与老年人力量减弱和瘦体重增加有关。

目的:胆碱是与运动训练相关的许多生理过程中必需的微量营养素，包括乙酰胆碱的生物合成。虽然饮食胆碱摄入量与耐力训练和表现之间的关系已经被研究过，但没有人研究过老年人抗阻运动训练(RET)期间的胆碱摄入量。该研究的目的是研究胆碱摄入量与老年人对RET的肌肉反应之间的关系。方法:46例60-69岁的个体(M=19, F=27)进行了12周的RET(3次/周，3组，8-12次，75%的最大力量[1RM]， 8个练习)。训练前后分别进行体成分(DEXA)和1RM测试。在分析了1656份饮食记录(3次/周，46名参与者，12周)后，参与者的平均胆碱摄入量被分为三组:低(2.9-5.5 mg/kg瘦肉/d)，中低(5.6-8.0 mg/kg瘦肉/d)或充足(8.1-10.6 mg/kg瘦肉/d)。结果:低组的复合力量(腿压+胸压1RM)增益显著低于其他组(低组:30.9±15.1%，中低组:70.3±48.5%，充足组:81.9±68.4%;p = 0.004)。加胆固醇、蛋白质或其他营养素的ANCOVA不会改变这一结果。与高胆碱摄入量(5.6-10.6 mg/kg瘦肉/d)相比，低胆碱组的瘦体重增加也有所减少(1.3±0.6% vs. 3.2±0.6%)。结论:这些数据表明，老年人群胆碱摄入量不足，低胆碱摄入量与RET肌肉反应呈负相关且独立相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Frailty & Aging GERIATRICS & GERONTOLOGY-

CiteScore

5.90

自引率

7.70%

发文量

期刊介绍： The Journal of Frailty & Aging is a peer-reviewed international journal aimed at presenting articles that are related to research in the area of aging and age-related (sub)clinical conditions. In particular, the journal publishes high-quality papers describing and discussing social, biological, and clinical features underlying the onset and development of frailty in older persons. The Journal of Frailty & Aging is composed by five different sections: - Biology of frailty and aging In this section, the journal presents reports from preclinical studies and experiences focused at identifying, describing, and understanding the subclinical pathophysiological mechanisms at the basis of frailty and aging. - Physical frailty and age-related body composition modifications Studies exploring the physical and functional components of frailty are contained in this section. Moreover, since body composition plays a major role in determining physical frailty and, at the same time, represents the most evident feature of the aging process, special attention is given to studies focused on sarcopenia and obesity at older age. - Neurosciences of frailty and aging The section presents results from studies exploring the cognitive and neurological aspects of frailty and age-related conditions. In particular, papers on neurodegenerative conditions of advanced age are welcomed. - Frailty and aging in clinical practice and public health This journal’s section is devoted at presenting studies on clinical issues of frailty and age-related conditions. This multidisciplinary section particularly welcomes reports from clinicians coming from different backgrounds and specialties dealing with the heterogeneous clinical manifestations of advanced age. Moreover, this part of the journal also contains reports on frailty- and age-related social and public health issues. - Clinical trials and therapeutics This final section contains all the manuscripts presenting data on (pharmacological and non-pharmacological) interventions aimed at preventing, delaying, or treating frailty and age-related conditions.The Journal of Frailty & Aging is a quarterly publication of original papers, review articles, case reports, controversies, letters to the Editor, and book reviews. Manuscripts will be evaluated by the editorial staff and, if suitable, by expert reviewers assigned by the editors. The journal particularly welcomes papers by researchers from different backgrounds and specialities who may want to share their views and experiences on the common themes of frailty and aging.The abstracting and indexing of the Journal of Frailty & Aging is covered by MEDLINE (approval by the National Library of Medicine in February 2016).