Clinical Significance of Antinucleolar Antibodies: Biomarkers for Autoimmune Diseases, Malignancies, and others.

IF 8.4 2区 医学 Q1 ALLERGY
Minoru Satoh, Angela Ceribelli, Tomoko Hasegawa, Shin Tanaka
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引用次数: 8

Abstract

Nucleolar staining is one of the standard patterns in immunofluorescence antinuclear antibodies (ANA), seen in 5-9% of ANA in various conditions. Antinucleolar antibodies (ANoA) are classified into 3 patterns in the International Consensus on ANA Patterns (ICAP) classification; AC-8 homogeneous pattern, AC-9 clumpy pattern, and AC-10 punctate pattern. Specificities known to show AC-8 include anti-Th/To, -PM-Scl, -nucleophosmin/B23, -nucleolin/C23, -No55, and others. AC-9 is seen by anti-fibrillarin/U3RNP and AC-10 by anti-RNA polymerase I and hUBF/NOR-90. ANoA has been classically known to be associated with scleroderma (SSc) and the characterization of nucleolar antigens identified several autoantigens recognized by SSc autoantibodies. The clinical association of anti-Th/To, PM-Scl, fibrillarin/U3RNP, and RNA polymerase I with SSc or SSc-overlap syndrome is well established, and commercial assays are developed. Anti-hUBF/NOR90, nucleophosmin/B23, and nucleolin/C23 are known for decades and reported in systemic autoimmune rheumatic diseases (SARDs), malignancies, graft versus host disease (GVHD), and others; however, their clinical significance remains to be established.

抗核抗体的临床意义:自身免疫性疾病、恶性肿瘤和其他疾病的生物标志物。
核仁染色是免疫荧光抗核抗体(ANA)的标准模式之一,在各种情况下可见5-9%的ANA。国际抗核抗体分类共识(ICAP)将抗核抗体(ANoA)分为3种类型;AC-8均质型,AC-9块状型,AC-10点状型。已知显示AC-8的特异性包括抗th / to, -PM-Scl, -核磷蛋白/B23, -核仁蛋白/C23, -No55等。AC-9通过抗纤原蛋白/U3RNP可见,AC-10通过抗rna聚合酶I和hUBF/ no -90可见。ANoA通常被认为与硬皮病(SSc)有关,核仁抗原鉴定出SSc自身抗体识别的几种自身抗原。抗th /To、PM-Scl、纤维蛋白/U3RNP和RNA聚合酶I与SSc或SSc重叠综合征的临床关联已经得到了很好的确立,并且正在开发商业检测方法。抗hubf /NOR90、核磷蛋白/B23和核仁蛋白/C23已被发现数十年,并在系统性自身免疫性风湿病(SARDs)、恶性肿瘤、移植物抗宿主病(GVHD)等疾病中报道;然而,其临床意义仍有待确定。
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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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