Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle.

Q4 Biochemistry, Genetics and Molecular Biology

Results and Problems in Cell Differentiation Pub Date : 2022-01-01 DOI:10.1007/978-3-031-06573-6_13

Mohammed El Dika, Andrew J Fritz, Rabail H Toor, Princess D Rodriguez, Stephen J Foley, Rahim Ullah, Daijing Nie, Bodhisattwa Banerjee, Dorcas Lohese, Kirsten M Tracy, Karen C Glass, Seth Frietze, Prachi N Ghule, Jessica L Heath, Anthony N Imbalzano, Andre van Wijnen, Jonathan Gordon, Jane B Lian, Janet L Stein, Gary S Stein

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引用次数: 0

Abstract

The cell cycle is governed by stringent epigenetic mechanisms that, in response to intrinsic and extrinsic regulatory cues, support fidelity of DNA replication and cell division. We will focus on (1) the complex and interdependent processes that are obligatory for control of proliferation and compromised in cancer, (2) epigenetic and topological domains that are associated with distinct phases of the cell cycle that may be altered in cancer initiation and progression, and (3) the requirement for mitotic bookmarking to maintain intranuclear localization of transcriptional regulatory machinery to reinforce cell identity throughout the cell cycle to prevent malignant transformation.

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表观遗传介导的基因表达调控用于生物控制和癌症：细胞周期调控机制的保真度。

细胞周期受严格的表观遗传机制控制，这些机制响应内在和外在的调控线索，支持 DNA 复制和细胞分裂的保真度。我们将重点关注：(1) 癌症增殖和损害控制所必需的复杂而相互依存的过程；(2) 癌症发生和发展过程中可能改变的与细胞周期不同阶段相关的表观遗传和拓扑结构域；(3) 有丝分裂书签的要求，以维持转录调控机制的核内定位，从而在整个细胞周期中强化细胞特性，防止恶性转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Results and Problems in Cell Differentiation Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Results and Problems in Cell Differentiation is an up-to-date book series that presents and explores selected questions of cell and developmental biology. Each volume focuses on a single, well-defined topic. Reviews address basic questions and phenomena, but also provide concise information on the most recent advances. Together, the volumes provide a valuable overview of this exciting and dynamically expanding field.