Depletion of vascular adaptive mechanisms in hypertension-induced injury of the heart and kidney.

IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Stancho Stanchev, Georgi Kotov, Boycho Landzhov, Vidin Kirkov, Lyubomir Gaydarski, Alexandar Iliev
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Abstract

Background: Vascular endothelial growth factor (VEGF) is a signalling protein of critical importance for angiogenesis. In an effort to better understand its significance in hypertension-induced injury of the heart and kidney we aimed at studying the changes in its expression in an experimental model and correlated it with capillary density in the myocardium and the renal parenchyma.

Methods: We used two age groups of spontaneously hypertensive rats (6- and 12-month-old), indicative of early and advanced hypertension. VEGF expression was assessed and a semi-quantitative analysis of its immunoreactivity was conducted. Changes in capillary density in the myocardium and kidney were assessed for statistical significance and correlations with VEGF expression were established.

Results: We reported stronger VEGF expression in animals with early compared to advanced hypertension in all examined structures. Capillary density decreased significantly at age 12 months compared to 6 months and was significant in all examined structures. A positive correlation was established between capillary density and the expression of VEGF.

Conclusion: These findings underscore the key significance of VEGF for compensatory angiogenesis and suggest that a statistically significant depletion of these vascular adaptive mechanisms is a major aspect in the cascade of hypertension-induced injury of the heart and kidney (Tab. 3, Fig. 26, Ref. 47).

高血压引起的心脏和肾脏损伤中血管适应性衰竭机制的研究。
背景:血管内皮生长因子(VEGF)是一种对血管生成至关重要的信号蛋白。为了更好地了解其在高血压性心脏和肾脏损伤中的意义,我们在实验模型中研究了其表达的变化,并将其与心肌和肾实质毛细血管密度的关系进行了研究。方法:我们使用两个年龄组自发性高血压大鼠(6月龄和12月龄),指示早期和晚期高血压。评估VEGF表达并半定量分析其免疫反应性。评估心肌和肾脏毛细血管密度的变化有无统计学意义,并与VEGF表达建立相关性。结果:我们报道了在所有检查的结构中,早期高血压动物比晚期高血压动物的VEGF表达更强。与6个月时相比,12月龄时毛细血管密度明显下降,所有检查的结构都明显下降。毛细血管密度与VEGF表达呈显著正相关。结论:这些发现强调了VEGF对代偿性血管生成的关键意义,并表明这些血管适应机制的统计学显著缺失是高血压引起的心脏和肾脏损伤级联的一个主要方面(表3,图26,参考文献47)。
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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
185
审稿时长
3-8 weeks
期刊介绍: The international biomedical journal - Bratislava Medical Journal – Bratislavske lekarske listy (Bratisl Lek Listy/Bratisl Med J) publishes peer-reviewed articles on all aspects of biomedical sciences, including experimental investigations with clear clinical relevance, original clinical studies and review articles.
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